수수(Sorghum)의 항돌연변이 및 항발암효과
Antimutagenic and Anticarcinogenic Effect of Sorghum
권영미, 박건영,
소속 상세정보
권영미 ( Kweon Young-Mi )
부산대학교 식품영양학과
박건영 ( Park Kun-Young )
부산대학교 식품영양학과
KMID : 0603519980030020128
Abstract
Antimutagenic effects of some cereals, legumes and oil seeds were studied using Ames test on Salmonella typhimurium TA 100. The methanol extracts of brown rice, sorghum, black seasame, white seasame, and Perilla seeds effectively inhibited the mutagenicity induced by aflatoxin Bl (AFBl). To separate and identify the antimutagenic and anticarcinogenic compounds from sorghum, the methanol extract was fractionated by using various solvents such as dichloromethane, ethylacetate and butanol. Among the solvent fractions from the methanol extract of sorghum, the dichloromethane fraction significantly reduced the mutagenicity induced by AFBl in Salmonella typhimurium TA 100. Using eukaryotic cells of C3H/10T1/2 cells, the anticarcinogenic effect of the methanol extract and the
dichloromethane fraction of sorghum was evaluated. It revealed that they inhibited the cytotoxicity of the MCA and reduced transformed foci induced by MCA.
키워드
Sorghum; Antimutagenic; Anticarcinogenic; C3H/10T1/2 cells
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