Ginsenoside Panaxadiol 및 Panaxatriol의 혈관 신생 억제 작용에 관한 연구
Anti-Angiogenic Effects of Ginsenoside Panaxadiol and Panaxatriol in Bovine Aortic Endothelial Cells
정주원, 문은정, 김신일, 백남인, 김규원,
소속 상세정보
정주원 ( Jung Joo-Won )
부산대학교 분자생물학과
문은정 ( Moon Eun-Jeung )
부산대학교 분자생물학과
김신일 ( Kim Shin-Il )
한국인삼연초연구소
백남인 ( Baek Nam-In )
한국인삼연초연구소
김규원 ( Kim Kyu-Won )
부산대학교 분자생물학과
KMID : 0603519990040020061
Abstract
It is generally accepted that ginsenoside Panaxadiol (PD), Panaxatriol (PT) have the anti-invasive and anti- metastatic activities. Angiogenesis is an essential process for metastasis of solid tumors. We examined the anti-angiogenic activity of PD and PT on the chorioallantoic membrane (CAM). In vivo CAM assay showed that PD and PT significantly reduced neovascularization. To investigate the roles of the PD, PT in the remodeling of endothelial cells, we performed MTT assay, tube formation assay and wounding migration assay using bovine aortic endothelial cells; PD and PT inhibited the proliferation, tube formation and migration. However, the expression of VEGF was not changed by treatment with PD and PT. These results suggest that inhibition of endothelial cell proliferation and migration by ginsenoside PD and PT contributes to the anti-angiogenic activities.
키워드
Ginsenoside; PD; PT; Angiogenesis
원문 및 링크아웃 정보
등재저널 정보