DMBA로 유발한 햄스터 협낭압에 대한 클로로필린의 억제 효과
The Inhibition of DMBA-Induced Carcinogenesis by CHL in Hanster Buccal Pouch
이종민, 정원윤, 박광균,
소속 상세정보
이종민 ( Lee Jong-Min )
연세대학교 치과대학 구강생물학교실
정원윤 ( Chung Won-Yoon )
연세대학교 치과대학 구강생물학교실
박광균 ( Park Kwang-Kyun )
연세대학교 치과대학 구강생물학교실
KMID : 0603519990040030127
Abstract
Chlorophyllin (CHL), a water-soluble derivative of chlorophyll, has been used for the treatment of several abnormal human conditions without apparent toxicity. Recent studies have revealed that CHL is antimutagenic and anticarcinogenic against various carcinogens in vitro and in vivo. In the present study, CHL exhibited dose-related inhibition of His + reversion in Salmonella typhimurium TA98 induced by 7,12-dimethylbenz[a]anthracene (DMBA). Formation of DNA adducts from DMBA was also attenuated in the presence of CHL. Topical application of CHL prior to the topical application of DMBA resulted in significant reduction in both in both incidence and multiplicity of tumors in hamster buccal pouch. These results suggest that CHL may act as a potential chemopreventive agent against oral cancer.
키워드
Chlorophyllin; DNA adduct; Antimutagenic activity; Anticarcinogenic activity
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