인돌 유도체들의 항산화 작용기전
Antioxidative Mechanism of Indole Derivatives
성도유, 박진생, 김명정, 노재경, 양영환, 백기주, 양융, 최진호, 이숙희, 정해영,
소속 상세정보
성도유 ( Soung Do-Yu )
부산대학교 약학대학
박진생 ( Park Jin-Seug )
부산대학교 의과대학
김명정 ( Kim Myung-Jung )
부산대학교 의과대학
노재경 ( No Jae-Kyung )
부산대학교 약학대학
양영환 ( Yang Young-Hwan )
부산대학교 약학대학
백기주 ( Paik Kee-Joo )
부산대학교 약학대학
양융 ( Yang Ryung )
연세대학교 생명공학과
최진호 ( Choi Jin-Ho )
부경대학교 식품생명과학과
이숙희 ( Lee Sook-Hee )
부산대학교 식품영양학과
정해영 ( Chung Hae-Young )
부산대학교 약학대학
KMID : 0603519990040040196
Abstract
Reactive oxygen species (ROS) mediate reactions which can damage a variety of critical biological molecules including DNA, proteins, and lipids. The present study was carried out to investigate the scavenging activities of indole derivatives against ROS and their scavenging mechanisms. Thus, eight indole derivatives were screened for the scavenging effects against O2-, H2O2, -OH, and ROS. Among them, indole derivatives with a hydroxyl group at the position 5 showed the strongest scavenging activitiy. 5-Hydroxyl indole derivatives significantly protected cultured PC12 and CPAE from damage induced by t-butylhydroperoxide (BHP). Especially, serotonin and N-acetyl 5-hydroxytryptamine showed the strongest cytoprotection. In vivo experiment, serotonin and N-acetyl 5-hydroxytryptamine reduced lipid peroxidation in ICR mice given BHP. In these experiments, serotonin and N-acetyl 5-hydroxytryptamine markedly showed the protective effect against ROS-induced stress in vivo and in vitro experiments.
키워드
Indole derivatives;Reactive oxygen species;Scavenging
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