Peroxynitrite Scavenging Activity of Phloroglucinol from Ecklonia stolonifera
정해영, 최혜리, 박혜진, 최재수, 최원철,
소속 상세정보
정해영 ( Chung Hae-Young )
부산대학교 약학대학
최혜리 ( Choi Hye-Rhi )
부산대학교 약학대학
박혜진 ( Park Hye-Jin )
부경대학교 식품생명과학과
최재수 ( Choi Jae-Sue )
부경대학교 식품생명과학과
최원철 ( Choi Won-Chul )
부산대학교 자연과학대학 생물학과
KMID : 0603520000050010001
Abstract
Peroxynitrite (ONOO-), formed by the reaction of superoxide (O2-) and nitric oxide (NO), is a cytotoxic species that can oxidize several cellular components such as proteins, lipids, and DNA. It has been implicated in diseases such as cancer, Alzheimer´s disease, rheumatoid arthritis, and atherosclerosis. Due to the lack of endogenous enzymes responsible for ONOO- inactivation, developing a specific ONOO- scavenger is considerably important. The aim of this study was to evaluate the ability of phloroglucinol isolated from E. stolonifera to scavenge ONOO- and to protect cells against ONOO-. Phloroglucinol was found to be as a potent ONOO- scavenger. The data demonstrated that phloroglucinol led to decrease ONOO- -mediated nitration of tyrosine through electron donation. Phloroglucinol provided cytoprotection from cell damage induced by ONOO-.
키워드
Peroxynitrite;scavenging activity;phloroglucinol;Nitrotyrosine;Cytoprotection;Smooth muscle cells
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