참치 정소 핵산복합물질이 면역활성에 미치는 영향
Effects of Nucleic Acids Comples of Tuna Testis on Immunological Activities
박상은, 김하원, 이승용, 김병각,
소속 상세정보
박상은 ( Park Sang-Eun )
서울대학교 약학대학 종합약학연구소
김하원 ( Kim Ha-Won )
서울시립대학교 생명과학과
이승용 ( Lee Seung-Ryong )
동원산업주식회사 식품연구소
김병각 ( Kim Byong-Kak )
서울대학교 약학대학 종합약학연구소
KMID : 0603520000050010015
Abstract
Tuna is one of the most abundant fish caught in Korea. The uncleic acids complex, DW-DNA, is produced in large amount from the testis. In this study, the effects of DW-DNA on humoral and cellular immune responses were examined. When administered orally in ICR mice, DW-DNA increased the number of peritoneal exudate cells twice of that of the control. The ratio of polymorphonuclear cells infiltrated into the peritoneal cavity increased from 2% to 40% by the oral administration of DW-DNA. Flow cytometry analysis showed that the cell numbers of macrophage and cytotoxic T lymphocyte of the mouse spleen increased in the S180-bearing mice group in the early stage of tumor growth. In the later stage, while the immune cells decreased in the control group, DW-DNA treated group restored the decreased immune cells to their normal level inth tumor-bearing group. In the nonspecific immune response of the mice, the acid phosphatase production and superoxide anion secretion by the activated macrophages in the DW-DNA given group increased by 1.6-fold and 1.3-fold, respectively, as compared with those of the tumor control group. These results indicate that the DW-DNA treated group restored the decreased immune response of the tumor-bearing mice to the normal level. Therefore it is concluded that DW-DNA may act as an immunomodulator.
키워드
Nucleotides; Immune response; B lymphocyte; Acid phosphatase; Superoxide anion; Macrophage
원문 및 링크아웃 정보
등재저널 정보