케일 추출물 및 클로로필린의 In vivo 항암 및 면역활성 증강효과
Antitumorigenic and Immunologic Effects of Kale Extracts and Chlorophyllin on Sarcoma 180 Cell-Transplanted Mice
이선미, 김광혁, 이숙희, 박건영,
소속 상세정보
이선미 ( Lee Sun-Mi )
부산대학교 식품영양학과
김광혁 ( Kim Kwang-Hyuk )
고신대학교 의과대학 미생물학교실
이숙희 ( Lee Sook-Hee )
부산대학교 식품영양학과
박건영 ( Park Kun-Young )
부산대학교 식품영양학과
KMID : 0603520000050010031
Abstract
In the present study, we examined tumor formation on sarcoma 180 cells-transplanted Balb/c mice, and phagocytic activity, nitroblue tertazolium (NBT) reduction rate and nitric oxide (NO) production on the Balb/c mice by the treatment of kale juice, kale methanol extract and chlorophyllin. The kale (Brassica oleracea var. acephala) juice, kale methanol extract and chlorophyllin decreased the growth of sarcoma 180 cells in vitro and inhibited the tumor formation by 67.9%, 71.0% and 61.9% compared to the control on sarcoma 180 cell transplanted Balb/c mice, respectively. The phagocytic activity and NBT reduction rate in peritoneal phagocytic cells of the Balb/c mice were considerably increased by the treatment of the kale extracts and chlorophyllin in comparison with the control group, however, no significant changes were observed by the treatments in the No production.
키워드
Kale; Chlorophyllin; Antitumor; Immunologic effect
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