The Effect of Aspirin on Preneoplastic Lesions in Rat Bladder Induced by N-Butyl-(4-hydroxybutyl) Nitrosamine
이길호, 송인호, 김형지, 이민철,
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이길호 ( Lee Gil-Ho )
단국대학교 의과대학 비뇨기과학교실
송인호 ( Sohng In-Ho )
단국대학교 의과대학 비뇨기과학교실
김형지 ( Kim Hyung-Jee )
단국대학교 의과대학 비뇨기과학교실
이민철 ( Lee Min-Chul )
단국대학교 의과대학 병리학교실
KMID : 0603520000050020065
Abstract
The effects of aspirin on the urinary bladder carcinogenesis in rats treated with N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN) were studied. The effects of chemoprevention of aspirin were evaluated with incidence of preneoplastic lesions. Forty-five female Sprague-Dawley rats were divided into three groups. Group A received 0.05% BBN in drinking water for 12 weeks. Group B received 0.05% BBN in drinking water with 0.5% aspirin in the diet for 12 weeks. Group C received control diet without added chemicals. The rats were sacrificed after 12 weeks. There were no typical preneoplastic lesions in the control group. Preneoplastic lesions such as simple hyperplasia, focal hyperplasia and papilloma were noted in Group A and B. The incidence of simple hyperplasia, focal hyperplasia and papilloma in Group A was 100%, 100% and 80%, respectively. The incidence of simple hyperplasia, focal hyperplasia and papilloma in Group B were 100%, 100% and 20%. Counts of focal hyperplasia and papilloma lesion in each rat were significantly reduced in Group B than in Group A (p<0.001). The result suggests that aspirin significantly decreases the incidence of precancerous lesions induced with BBN and it can act as an effective cheomopreventive agent for precancerous lesions in urinary bladder.
키워드
Carcinogenesis; Bladder tumor; Chemoprevention; Aspirin
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