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Anticarciogenic Effect of Kimchi Extract on 2-AAF-induced Rat Hepatocarcinogenesis System
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¹Ú°Ç¿µ ( Park Kun-Young )
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±èÇüÁø ( Kim Hyoung-Chin )
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Á¤±Ù¿Á ( Jung Keun-Ok )
ºÎ»ê´ëÇб³ ½ÄÇ°¿µ¾çÇаú
KMID : 0603520000050020081
Abstract
Anticarcinogenic effect of the methanol extract from kimchi was determined in a new medium-term carcinogenicity bioassay using D-galactosamine (DGA) as a nonsurgical method to induce liver cell regeneration in place of partial hepatectomy (PH). Male F344 rats were initially given a single i.p. injection of diethylnitrosamine (DEN, 200 §·/§¸) and received 2 i.p. injections of D-galactosamine (DGA, 300 §·/§¸) at the end of week 2 and 5. They were treated with oral administration of 2-acetylaminofluorene (2-AAF, 7 §·/§¸) and kimchi extract (920 §·/§¸) for week 3¡8 (5 days/week). Anticarcinogenic effect was assessed by comparing the numbers and areas per square centimeter of glutathione S-transferase placental form-positive (GST-P+) foci in the livers of kimchi extract-treated animals with those of the control animals given 2-AFF alone. No difference was noted in body weights between control and kimchi treated
group. Liver weights and liver/body weight ratios were not changed in rats treated with kimchi sample. The mean numbers of GST-P+ foci in livers of control and kimchi-treated group were 13.8 and 8.8/§¯2, respectively. The areas of GST-P+
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Kimchi; GST-P; foci; 2-AAF; Hepatocarcinogenesis
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