Anticarcinogenicity of Various Ginseng Fractions and Components in Red Ginseng Using Yun’s Anticarcinogenicity Test Model
윤택구, 이윤실, Choi Kwang-Joo, 이유희, 윤효영,
소속 상세정보
윤택구 ( Yun Taik-Koo )
원자력병원 실험병리학연구실
이윤실 ( Lee Yun-Sil )
원자력병원 실험병리학연구실
( Choi Kwang-Joo )
한국인삼연초연구소
이유희 ( Lee You-Hui )
한국인삼연초연구소
윤효영 ( Yun Hyo-Yung )
Chungbuk National University
KMID : 0603520000050040186
Abstract
Cancer could be conquered by early diagnosis and primary prevention through many non-toxic cancer preventives ’neutraceutical’ have been discovered Our study has been focused on the anticarcinogenicity of Panax ginseng C. A. Meyer, also known as mystic tonic, against various chemical carcinogens. Experimental and epidemiological findings showed that red ginseng and heated fresh ginseng extract had anticarcinogenic and cancer preventive effects. To identify its active components, several extracts and components of red ginseng and fresh ginseng were tested for anticarcinogenicity using Yun’s 9 week medium term assay. Ethanol extract, water extract and total saponin fraction isolated from 6 year-old fresh ginseng significantly inhibited mouse lung adenoma incidence, suggesting that saponin might be the active components. Furthermore, since red ginseng among the ginseng types, showed the most effective anticarcinogenicity, semi-synthesized ginsenoside Rg3 and Rg5 mixture, major saponi n components in red ginseng, were selected for further study. The results showed significant inhibition of lung adenoma in Yun’s anticarcinogenicity test system, indicating that ginsenoside Rg3 or Rg5 alone or together would be active anticarcinogenic compounds.
키워드
Anticarcinogenicity; Ginseng; Red ginseng; Ginseng fractions; Minor ginsenosides
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