유근피(楡根皮), 비파엽(秕杷葉) 및 인진호(茵蔯蒿) 추출 제제의 Nude Mice 종양 성장 억제 효과
Tumor Suppress Effects of Extracts from Ulmus pumila, eriobotrya japonica, and Artemisia capillaris Thunb in Nude Mice
이선영, 이찬, 김인호, 류재웅, 임준규, 김상우, 최승기, 김세현, 오유경, 김승조,
소속 상세정보
이선영 ( Lee Sun-Young )
포천중문의과대학교 분당차병원 부인암센터
이찬 ( Lee Chan )
포천중문의과대학교 분당차병원 부인암센터
김인호 ( Kim In-Ho )
포천중문의과대학교 분당차병원 부인암센터
류재웅 ( Ruy Jae-Oong )
가톨릭대학교 의과학연구원
임준규 ( Lim Jun-Kyu )
포천중문의과대학교 분당한방병원
김상우 ( Kim Sang-Woo )
포천중문의과대학교 분당한방병원
최승기 ( Choi Seung-Ki )
포천중문의과대학교 분당한방병원
김세현 ( Kim Se-Hyun )
포천중문의과대학교 예방의학교실
오유경 ( Oh Yu-Kyoung )
포천중문의과대학교 미생물학교실
김승조 ( Kim Seung-Jo )
포천중문의과대학교 분당차병원 부인암센터
KMID : 0603520010060010019
Abstract
Ulmus pumila, Eriobotrya japonica Lindl, and Artemisia capillaris Thunb have been used as anticancer folk medicines in Korea. In this study, we report the suppress effects of the extracts obtained from these herbs against tumors in nude mice. HeLa cells were injected into the nude mice after 1 month of oral pretreatment with usual care diet, nutritious raw food, or the mixture of usual diet and herbal extract in a pellet form. After injection of HeLa cells, the nude mice received either usual care diet, nutritious raw food, or the mixture of usual diet supplemented with the herbal extracts for two months. After tumor induction, the weight change of the nude mice were significantly lower in herbal extract-treated groups than the nutritious raw food group or the control group given usual care diet throughout the experiments. The herbal extracts suppressed the growth of tumors in nude mice, showing as high as 50% and 34% of tumor size reduction at one month and two months after tumor induction, respectively. These results indicate the potential use of the extract obtained from Ulmus pumila, Eriobotrya japonica, and Artemisia capillaris Thunb as a food supplement for cancer patients.
키워드
Herbal extracts; Ulmus; Eriobotrya; Artemisia; HeLa cell; Nude mice; Tumor growth; Suppress effects
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