한국 여성의 자궁경부 조직에서 고위험 Human Papillomavirus 10개 유전형의 감염 빈도에 기초한 HPV 예방 백신의 구성 방안 연구
Study on the Proper Composition of Human Papillomavirus Vaccine Based on the Prevalence of Ten High-risk Human Papillomaviruses Infection in Uterine Cervical Cancerous and Noncancerous Tissues Obtained from Korean Women
김문홍, 김용범, 이철민, 노주원, 김재원, 박노현, 송용상, 강순범, 이효표,
소속 상세정보
김문홍 ( Kim Moon-Hong )
서울대학교 의과대학 산부인과학교실
김용범 ( Kim Yong-Beom )
서울대학교 의과대학 산부인과학교실
이철민 ( Lee Chul-Min )
서울대학교 의과대학 산부인과학교실
노주원 ( Roh Ju-Won )
서울대학교 의과대학 산부인과학교실
김재원 ( Kim Jae-Won )
서울대학교 의과대학 산부인과학교실
박노현 ( Park Noh-Hyun )
서울대학교 의과대학 산부인과학교실
송용상 ( Song Yong-Sang )
서울대학교 의과대학 산부인과학교실
강순범 ( Kang Soon-Beom )
서울대학교 의과대학 산부인과학교실
이효표 ( Lee Hyo-Pyo )
서울대학교 의과대학 산부인과학교실
KMID : 0603520010060020067
Abstract
Objective: Three are more than 20 cancer-associated HPV types, but little is known about the prevalence of HPV types in Korean women. Our aim was to investigate the prevalence of 10 high-risk HPV types in samples obtained from Korean women in order to establish a strategy of HPV vaccine development for Korean women.
Materials and Method: Cervical scrapes or tissues collected from a total of 781 women were tested for the presence of HPV types 16, 18, 31, 33, 35, 45, 51, 52, 56, 58 by multiplex nested PCR system developed by our laboratory recently.
Results: Among evaluable 751 samples, 153 with invasive cervical cancer (ICC), 56 with cervical intraepithelial neoplasia (CIN) and 542 with benign gynecologic disease(BGD), HPV DNA of any type was detected in 372 (49.5%) samples in total,71.9% in ICC, 67,9% in CIN, 41.3% in BGD. HPV 16 and 18 were detected in 77 and 19 cases of ICC, 26 and 5 cases of CIN, 125 and 30 of BGD, respectively. The most frequently detected HPV type in ICC was 16 and followed by 18, 33, 31, 52, 58, 51, 45, 56, 35 in decreasing order. Nearly 80% of ICC contain either HPV 16, 18, 31, or 33. Among 372 cases detected to contain HPV DNAs, 272 (73.1%) cases were infected with single HPV type, 79 (21.2%) cases with two types, 19 (5.1%) cases with three types, and only two cases with four types. There was significant difference in single infection rate between CIN and BGD, and borderline significance between cervical cancer and BGD.
Conclusions: In Korean women, mixed infection with multiple HPV types occurs in nearly 30% of infected women. HPV type distribution appears somewhat dissimilar in this report with that of previous reports from other countries. These data may be relevant to the rational design of prophylactic HPV vaccine strategies.
키워드
Cervical cancer; Human papillomavirus; Multiplex PCR; Korean women; HPV vaccine
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