KC1 혼합죽염의 보돌연변이감소 및 항돌연변이효과
Reduced Comutagenic and Antimutagenic Effects of Bamboo Salt Prepared with KC1 and NaC1
정근옥, 이선미, 이숙희, 박건영,
소속 상세정보
정근옥 ( Jung Keun-Ok )
부산대학교 식품영양학과
이선미 ( Lee Sun-Mi )
부산대학교 식품영양학과
이숙희 ( Lee Sook-Hee )
부산대학교 식품영양학과
박건영 ( Park Kun-Young )
부산대학교 식품영양학과
KMID : 0603520010060030140
Abstract
To reduce the effect of salt on mutagenicity, the KC1 mixed (chunil salt : KC1=3~7 : 7~3) bamboo salt (BS) was developed. Comutagenic/antimutagenic effects of KC1 mixed BS were investigated in Ames test, SOS chromotest and micronucleaus test. All the salts studied showed comutagenic effects on the N-methyl-N’-nitro-N-nitrosoguanidine (MNNG) in Salmonella typhimurium TA100. One time heat treated BS1 X K7 (chunil salt : KC1= 3 : 7) exerted the lowest comutagenic activity among the salts. In SOS chromotest using E. coli PQ37, Guwoon salt (GS), 9 times heat treated BS and the KC1 mixed BS samples blocked the SOS response induced by MNNG, while purified salt (PS) increased the SOS induction factor. One time heat treated BS1 X K7 exhibited the highest antimutagenic activity among the KC1 mixed BS. The induction of chromosome abberations by mitomycin C was increased by pre-treatment with salt. However, GS and 9 times heat treated BS significantly decreased the frequency of micronucleated reticulocytes compared to the PS (p<0.05). One time heat treated BS had more suppressive effects on chromosome abberation than KC1 and the mixture of chunil salt and KC1 (3 : 7). These result indicated that the KC1 mixed BS1 X K7 showed the lowest comutagenic effects among the salts and the ratio of K and Na was important factor to reduce comutagenicity or to increase antimutagenicity of salt in the mutagenicity test system.
키워드
KC1; Bamboo salt; Comutagenicity; Antimatagenicity
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