포공영 에탄올추출물이 발암개시에 미치는 영향
Effect of Taraxacum mongolieum Hand-Mass Ethanol Extract on Initiation of Carcinogenesis
손윤희, 남경수,
소속 상세정보
손윤희 ( Shon Yun-Hee )
동국대학교 의과대학 약리학교실
남경수 ( Nam Kyung-Soo )
동국대학교 의과대학 약리학교실
KMID : 0603520020070010013
Abstract
Ethanol extract of Taraxacum mongolieum Hand-Mass (TMEE) was investigated for the effect on the phase I enzyme and carcinogen-DNA adduct formation. At 2.5, 125, and 25 mg/ml of TMEE, the binding of [³H]B[a]P metabolites to DNA of NCTC-clone 1469 cells was inhibited by 38.0%, 77.8%, and 68.5%, respectively. There was slight inhibition in the activity of cytochrome P450 IAl enzyme with the treatment of TMEE. These results suggest that TMEE has chemopreventive potential by inhibiting cytochrome P450 IAl activity and benzo[a]pyrene-DNA adduct formation.
키워드
Taraxacum mongolieum Hand-Mass; Cytochrome P450 lAI; Carcinogen-DNA adduct
원문 및 링크아웃 정보
등재저널 정보