Telomere의 기능 손실에 의한 Telomerase 결핍 세포의 성장 억제에 대한 연구
Impaired Growth of Telomerase-Deficient Cells by Telomere Dysfunction
주연진, 박정은, 전경미, 김창민, 김상훈, 박원봉, 이기호,
소속 상세정보
주연진 ( Ju Yeun-Jin )
원자력의학원 방사선의학연구센터
박정은 ( Park Jeong-Eun )
원자력의학원 방사선의학연구센터
전경미 ( Juhn Kyoung-Mi )
원자력의학원 방사선의학연구센터
김창민 ( Kim Chang-Min )
국립암센터 간암센터
김상훈 ( Kim Sang-Hoon )
경희대학교 이과대학 생물학과
박원봉 ( Park Won-Bong )
서울여자대학교 자연과학대학 화학과
이기호 ( Lee Kee-Ho )
원자력의학원 방사선의학연구센터
KMID : 0603520020070030161
Abstract
Gradual loss of telomere ends limits the growth capacity of primary cells whereas telomerase reactivation facilitates telomere maintenance and immortal cell growth in over 85% of human cancers. While telomerase activity is not detectable in most human somatic cells, inhibition of telomerase activity is thought to be a potential target for anticancer therapies. Here we show that telomerase inhibition has a profound effect on cell growth in mouse embryonic fibroblasts (MEFs) derived from telomerase-deficient mice. Telomere dysfunction exemplified by the formation of chromosomal end-to-end fusions was found to be an important factor of the growth impairment in telomerase-deficient cells. Multi-chromosomal fusion after exposure to doxorubicin is a typical characteristic of chromosomal abnormality. These findings indicate that chromosomal end-to-end fusion is a critical factor for the impairment of cell growth in telomerase-deficient cells and multi-chromosomal fusion might be one mechanistic basis of doxorubicin in conjunction with telomere function.
키워드
Telomerase;Telomere;Chromosomal end to fusion;Cell growth
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