한국여성의 유방암 발병에 있어 Methylenetetrahydrofolate Reductase(MTHFR) 유전자 다형성과 식이 간의 상호관련성
Interaction of Methylenetetrahydrofolate Reductase Genetic Polymorphism with Diet in Breast Cancer in Korean Women
이상아, 김동현, 유근영, 안세현, 노동영, 조국진, 강대희,
소속 상세정보
이상아 ( Lee Sang-Ah )
서울대학교 의과대학 예방의학교실
김동현 ( Kim Dong-Hyun )
한림대학교 의과대학 사회의학교실
유근영 ( Yoo Keun-Young )
서울대학교 의과대학 예방의학교실
안세현 ( Ahn Sei-Hyun )
울산대학교 의과대학 서울아산병원 외과학교실
노동영 ( Roh Dong-Young )
서울대학교 의과대학 외과학교실
조국진 ( Choe Kook-Jin )
서울대학교 의과대학 외과학교실
강대희 ( Kang Dae-Hee )
서울대학교 의과대학 예방의학교실
KMID : 0603520020070030185
Abstract
To evaluate the interactive effect of methylenetetrahydrofolate reductase (MTHFR) genotype and dietary factors on the development of breast cancer, a hospital based case-control study was conducted in South Korean study population consisting of 189 histologically confirmed incident breast cancer cases and their 189 age-matched controls without present or previous history of cancer. A PCR-RFLP method was used for the genotyping of MTHFR (C677T) and statistical evaluations were performed by unconditional logistic regression analysis. Consumption of some dietary factors, such as, green vegetables (OR=0.3, 95%CI: 0.2-0.6), white vegetables (OR=0.3, 95%CI: 0.1-0.7) mushrooms (OR=0.4, 95%CI: 0.3-0.7), and meats (OR=1.7, 95%CI: 1.1-2.8) significantly decreased or increased the risk of breast cancer. Although the breast cancer risk was 1.7-fold (95% CI: 0.8-3.2) increased in women with MTHFR TT genotype, the association was not statistical significant. Women with MTHFR TT genotype and low green vegetable intake increased 5.6-fold risk of breast cancer compared to high green vegetable intake group containing MTHFR CC/CT genotype. Women with MTHFR TT genotype and low mushroom intake increased 4.4-fold risk of breast cancer compared to women with high mushroom intake containing MTHFR CC/CT genotype. However, the interaction was not significant (p for trend=0.96, for green vegetable; p for interaction=0.56, for mushroom). Our findings suggest that MTHFR polymorphism did not influence individual susceptibility to breast cancer. However MTHFR (C667T) genotype and some diet intakes appeared to have the interactive effect in breast cancer development.
키워드
MTHFR;Genetic polymorphism;Green vegetable;Mushrooms;Breast cancer
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