정자발생의 필수성분으로서 셀레늄과 셀레노프로테인
Selenium and Selenoproteins as the Essential Elements for Spermatogenesis
백인정, 남상윤,
소속 상세정보
백인정 ( Baek In-Jeoung )
Chungbuk National University
남상윤 ( Nam Sang-Yoon )
Chungbuk National University
KMID : 0603520030080010053
Abstract
Selenium (Se) is an essential micronutrient for mammals and its biological functions are mediated by a selenoprotein. Many studies have shown that the testis is one of the main target organs for Se and that a long Se-deficient state produces abnormal sperms with impaired motility due to characteristic midpiece damage and finally induces a male infertility. In the tests of animals injected an exogenous Se, Se particles are observed mainly in the cytoplasms of spermatogonia, spermatocytes, and Leydig cells. Moreover, the selenoproteins focused on the testis, mitochondrial capsule selenoprotein (MCS) and phospholipid hydroperoxide glutathione peroxidase (PHGPx), are also expressed in the spermatogenic cells and Leydig cells. These indicate that Se and selenoproteins play an important part in the spermatogenesis. In future, to establish the function of Se and selenoprotein during spermatogenesis, more studies would necessary.
키워드
Spermatogenesis; Selenium; Mitochondrial capsule selenoprotein(MCS); Phospholipid hydroperoxide glutathione peroxidase (PHGPx)
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