Curcuma xanthorrjiza 에서 분리된 Xanthorrhizol의 화학적 암예방 효과
Chemopreventive Effect of Xanthorrhizol from Curcuma xanthorrhiza
박재희, 김미정, 박광균, Kim Heui-Og, 황재관, 정원윤,
소속 상세정보
박재희 ( Park Jae-Hee )
연세대학교 치과대학 구강생물학교실
김미정 ( Kim Mi-Jeong )
연세대학교 치과대학 구강생물학교실
박광균 ( Park Kwang-Kyun )
연세대학교 치과대학 구강생물학교실
( Kim Heui-Og )
연세대학교 치과대학 구강생물학교실
황재관 ( Hwang Jae-Kwan )
연세대학교 생명공학과
정원윤 ( Chung Won-Yoon )
연세대학교 치과대학 구강생물학교실
KMID : 0603520030080020091
Abstract
Xanthorrhizol is a sesquiterpenoid isolated from Curcuma xanthorrhiza that has been known to possess anti-inflammatory and anti-carcinogenic effects. In this work, we have found that xanthorrhizol reduced superoxide anion generation by 12-O-tetradecanoylphorbol- 13-acetate (TPA) in differentiated HL-60 cells and exerted a dose-related inhibition of His+ reversion in Salmonella typhimurium TA102 induced by tert-butylhydroperoxide (t-BOOH) and hydrogen peroxide. Pretreatment of xanthorrhizol significantly decreased the incidence and the multiplicity of mouse skin tumors stimulated by TPA for 19 weeks after a single application of dimethylbenz[a]anthracene (DMBA), and mitigated the expression of epidermal ornithine decarboxylase in the skins. These results demonstrate that xanthorrhizol may be a potent cancer chemopreventive agent.
키워드
Curcuma xanthorrhiza; Xanthorrhizol; Chemopreventive agent
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