마우스의 항암 세포활성에 미치는 키토산의 효과
Effects of Chitosan on Anti-tumor Cellular Activity in Mice
정양숙, 정현기, 박건영, 김광혁,
소속 상세정보
정양숙 ( Chung Yang-Sook )
고신대학교 의과대학 미생물학교실
정현기 ( Chung Hyun-Kee )
고신대학교 의과대학 소아과학교실
박건영 ( Park Kun-Young )
부산대학교 식품영양학과
김광혁 ( Kim Kwang-Hyuk )
고신대학교 의과대학 미생물학교실
KMID : 0603520030080020107
Abstract
A main goal of cancer research is to completely prevent recurrence following surgery and to increase survival time. Cytotoxic anticancer chemotherapeutic agents generally produce severe side effects, while reducing host resistance to cancer and infections, especially through the destruction of lymphoid and bone marrow cells. In this study, we have investigated the effect of chitosan on lymphocyte proliferation, natural killer (NK) cell activity, and monocyte activity in mice. Mice splenocytes were incubated with chitosan and Concanavalin A to observe the effects on cell proliferation. The cytotoxic activities of NK cell and monocyte in chitosan-exposed mice were assayed by cytotoxicity against Yac-1 cells. We detected an increase of cell growth in splenocytes proliferation. The cytotoxic activities of NK cell and monocyte in chitosan-exposed mice were increased in comparison with control. Our results suggest that chitosan augments lymphocyte proliferation, and activation of NK cells and monocyte.
키워드
Chitosan; Lymphocyte proliferation; NK; Monocyte
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