Caffeic Acid의 ONOO^(-) 제거활성
Peroxynitrite(ONOO^(-)) Scavenging Activity of Caffeic Acid
이지영, 성도유, 노재경, 김유정, 제정환, 김민선, 최재수, 정해영, 이경희,
소속 상세정보
이지영 ( Lee Ji-Young )
부산대학교 유전공학연구소
성도유 ( Soung Do-Yu )
부산대학교 약학대학
노재경 ( No Jae-Kyung )
부산대학교 약학대학
김유정 ( Kim You-Jung )
부산여자대학 피부미용과
제정환 ( Je Jeong-Hwan )
부산대학교 약학대학
김민선 ( Kim Min-Sun )
부산대학교 약학대학
최재수 ( Choi Jae-Sue )
부경대학교 식품생명과학과
정해영 ( Chung Hae-Young )
부산대학교 유전공학연구소
이경희 ( Lee Kyung-Hee )
부산대학교 약학대학
KMID : 0603520030080030173
Abstract
Peroxynitrite (ONOO) is produced! by the reaction of superoxide (02) with nitric oxide (NO). ONOO is a powerful oxidant that can cause damages of proteins, lipids, and DNA through more subtle action mechanism, which is called the process of nitration and oxidation. Nitrotyrosine has served as a fingerprint for ONOO mediated damage of cellular proteins in a variety of pathological conditions. Because the body lacks endogenous defense components against ONOO - induced protein modifications, ONOO scavengers should be supplemented. In the present study, caffeic acid showed evidence of scavenger for ONOO -. A dihydroxyl group and a double bond seem to be essential structure requirements. The data from the experiments confirmed a protective effect of caffeic acid on bovine serum albumin (BSA) and low-density lipoprotein (LDL) against ONOO . Further, caffeic aicd was found to protect tert-butyl hydroperoxide (t-BHP)-mediated ROS generation in vascular endothelial cells. The present study demonstrated that caffeic acid with hydroxyl groups and double bonds exerts an anti-nitration effect by scavenging ONOO through electron donation.
키워드
Caffeic acid;Peroxynitrite(ONOO^(-));Scavenger;Nitration
원문 및 링크아웃 정보
등재저널 정보