위암예방
chemoprevention of Gastric Cancer
홍원선,
소속 상세정보
홍원선 ( Hong Weon-Seon )
울산대학교 의과대학 서울아산병원 소화기내과학교실
KMID : 0603520040090010001
Abstract
Gastric cancer is one of the most prevalent malignancies in Korea. The pathogenesis of gastric cancer, especially adenocarcinoma, includes increased cellular proliferation, increased free oxygen radical, decreased apoptosis, abnormalities of repair gene or overexpression of cyclooxygenase-2. Genetic damage by increased cellular proliferation and free oxygen radical goes to malignant change. Helicobacter pylori infection causes chronic gastritis known as a premalignant lesion. For prevention of gastric adenocarcinoma, it is necessary to avoid carcinogen. The long term ingestion of nitrates in salted, smoked foods seems to be related to a higher risk. Fresh vegetables and fruits appear to have chemopreventive effect for gastric adenocarcinoma. Vitamin A, C, E, carotenoids, selenium, soybean or green tea have potent antioxidant activity to prevent carcinogenesis. The effect of H. pylori eradication on the risk for gastric cancer is still under investigation.
키워드
Gastric cancer;Adenocarcinoma;Chemoprevention; Genetic damage; Helicobacter pylori
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