인간유방상피세포에서 암예방물질에 의한 침윤성 억제 및 세포사멸 유도
Inhibition of Invasive Phenotype and Induction of Apoptosis in Human Breast Cancer Cells by Chemopreventive Agents
김인영, 문애리,
소속 상세정보
김인영 ( Kim In-Young )
덕성여자대학교 약학대학
문애리 ( Moon Aree )
덕성여자대학교 약학대학
KMID : 0603520040090020059
Abstract
The most effective way to deal with cancer would be to prevent development of the cancer. Cancer chemoprevention is the treatment to block initiation or promotion- progression phases. Cancer metastasis represents the most important cause of cancer death and anti-tumor agents that may inhibit this process have been pursued. Ras expression has been suggested as a marker for tumor aggressiveness of breast cancer, including the degrees of invasion and tumor recurrence. In this review article, we summarized several chemopreventive agents which inhibit invasive phenotype and/or induce apoptosis of H-ras-transformed MCF10A human breast epithelial cells. The molecular mechanism(s) underlying the cancer chemopreventive effects are also reviewed. A potential use of natural products including apicidin, Aster, curcumin and capsaicin for human breast cancer chemoprevention has been suggested.
키워드
Apicidin;Aster;Curcumin;Capsaicin;H-ras;MCF10A cells;Invasion;Migration;MMP-2;Apoptosis
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