식품유래 파이토케미칼들의 암예방 작용
Cancer Chemopreventive Effects of Dietary Phytochemicals
서영준,
소속 상세정보
서영준 ( Surh Young-Joon )
서울대학교 약학대학
KMID : 0603520040090020068
Abstract
Chemoprevention is an attempt to use either naturally occurring or synthetic substances or their mixtures to inhibit, reverse, or delay the progress of carcinogenesis, before the malignancy manifests. Numerous chemical substances have been found to prevent or halt carcinogenesis, and it is noticeable that a substantial body of chemopreventive agents are derived from our daily diet, particularly vegetables and fruits (Surh, Y.-J., Nature Rev. Cancer, 2003). Accumulating evidence from population-based and laboratory studies support association between regular consumption of fruits and vegetables and the reduced risk of certain cancers. A wide array of phytochemicals derived from edible plants have been reported to possess ability to intervene in a specific stage of carcinogenic process. Multiple mechanisms have been proposed to account for the anti-carcinogenic actions of dietary constituents, but more attention has recently been focussed on intracellular signaling cascades as common molecular targets of a vast variety of chemopreventive phytochemicals.
키워드
Chemoprevention;Phytochemicals;Signal transduction;NF-kappa B;AP-1;Mitogen-activated protein kinases;Nrf2;Beta-catenin
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