솔잎첨가 생식의 암예방 효과
Cancer Preventive Effects of Saengshik, a Formulated Health Food, Prepared with Pine Needle
길정하, 공창숙, 문숙희, 박건영,
소속 상세정보
길정하 ( Kil Jeung-Ha )
부산대학교 식품영양학과
공창숙 ( Kong Chang-Suk )
부산대학교 식품영양학과
문숙희 ( Moon Suk-Hee )
경남정보대학 식품과학계열
박건영 ( Park Kun-Young )
부산대학교 식품영양학과
KMID : 0603520040090020084
Abstract
Antimutagenic effects of methanol extracts from various kinds of vegetables were evaluated to develop Saengshik having cancer preventive effect. Among the various kinds of vegetables, pine needle showed the highest antimutagenic activity. Thus, the Saengshik recipes were prepared by adding different levels of pine needle (2%, 6%, 10% and 20% level in Saengshik I, II, III and IV, respectively). Antimutagenic and anticlastogenic effects of methanol extracts from Saengshik were investigated using Ames test and supravital staining micronucleus assay in the ICR mice. Increased content of pine needle in the Saengshik led to high inhibitory effects on the carcinogens (MNNG and AFB1)- induced mutagenicities. In vivo anticlastogenic effects of the Saengshik (Saengshik I and III) were evaluated by supravital staining micronucleus assay in the ICR mice. The developed Saengshik significantly decreased mtomycin C - induced clastogenicity (p＜0.05). Among the Saengshik, Saengshik III containing 10% pine needle was the most effective.
키워드
Pine needle;Saengshik;Antimutagenic effect;Anticlastogenic effects
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