한국인 간세포암 환자에서 경피적 에탄올 주입술의 치료 효과
Efficacy of Percutaneous Ethanol Injection Therapy in Korean with Hepatocellular Carcinoma
소속 상세정보
강현우/Kang HW
김윤준/김강모/강정묵/김수환/김진현/윤원재/윤정환/윤용범/이효석/Kim YJ/Kim KM/Kang JM/Kim SH/Kim JH/Yoon WJ/Yoon JH/Yoon YB/Lee HS
KMID : 0614620030420060502
Abstract
BACKGROUND/AIMS: Percutaneous ethanol injection therapy (PEIT) is widely used for the treatment of hepatocellular carcinoma (HCC). However, its long-term therapeutic efficacy is not verified in Korea, one of hepatitis B virus (HBV) endemic areas. Thus, this study was to assess its efficacy and prognostic factors affecting tumor-free survival following PEIT in Korean HCC patients.
METHODS: From 1997 to 1999, 100 consecutive patients who had 1 to 3 HCC nodules of maximum diameter less than 3 cm and underwent PEIT were enrolled. Therapeutic efficacy, overall and tumor-free survival rates were assessed during follow-up periods.
RESULTS: In 83 patients, HCC nodules were completely ablated by PEIT. The cumulative 1, 2, and 3 year overall survival rates were 98%, 96%, and 88%, respectively. The cumulative 1, 2, and 3 year tumor-free survival rates were 73%, 50%, and 37%, respectively. Larger tumors ( 2 cm) were associated with a higher local recurrence rate.
CONCLUSIONS: These results demonstrate that PEIT is therapeutically useful in patients with HCC less than 4 in number and less than 3 cm in diameter. However, since multiple or large tumors are associated with low tumor-free survival or high local recurrence rates, PEIT for these tumors and the subsequent post-treatment follow-up should be performed carefully.
키워드
간세포암; 경피적 에탄올 주입술; 생존율; 재발; Carcinoma; hepatocellular; Percutaneous ethanol injection; Survival; Recurrence
원문 및 링크아웃 정보
등재저널 정보