진단 전 흡연과 음주 행태와 위암 환자의 생존율: 전향적 환자 코호트 연구
Prediagnostic Smoking and Alcohol Drinking and Gastric Cancer Survival: A Korean Prospective Cohort Study
김신아, 최보율, 송규상, 박찬혁, 은창수, 한동수, 김용성, 김현자,
소속 상세정보
김신아 ( Kim Shin-Ah )
강릉원주대학교 생명과학대학 식품영양학과
최보율 ( Choi Bo-Youl )
한양대학교 의과대학 예방의학교실
송규상 ( Song Kyu-Sang )
충남대학교 의과대학 병리학교실
박찬혁 ( Park Chan-Hyuk )
한양대학교 의과대학 내과학교실
은창수 ( Eun Chang-Soo )
한양대학교 의과대학 내과학교실
한동수 ( Han Dong-Soo )
한양대학교 의과대학 내과학교실
김용성 ( Kim Yong-Sung )
한국생명공학연구원
김현자 ( Kim Hyun-Ja )
강릉원주대학교 생명과학대학 식품영양학과
Abstract
Background/Aims: Behavioral factors, such as smoking and heavy alcohol consumption, increase the risk of gastric cancer (GC), but their effects on survival are not clear. We examined associations between prediagnostic smoking and alcohol drinking behavior and GC death by long-term follow-up.
Methods: The participants were 508 GC patients enrolled at Chungnam University Hospital and Hanyang University Guri Hospital from 2001 to 2006. Information on clinicopathologic and behavioral risk factors was collected, and patient survival was prospectively followed until 2016 by medical chart review and telephone survey.
Results: During above 10 years follow-up period, overall death was 46.2% (n=226) and GC deaths was 38.2% (n=187) among the 489 GC patients included in the analysis. No significant association was found between smoking habits and overall or GC survival. However, after stratification by histological type, the hazard ratio (HR) of GC death for current smokers tended to be higher for the diffuse type (HR 1.61, 95% CI 0.57?4.59 for current vs. never) rather than for the intestinal type (HR 0.78, 95% CI 0.28?2.19 for current vs. never). Light alcohol consumption was found to be associated with a significantly lower risk of GC death (HR 0.52, 95% CI 0.36?0.75 for <20 g/day for women or <40 g/day for men vs. never and past), and the effects of alcohol drinking habits had similar effects on GC death for the intestinal and diffuse types.
Conclusions: These results suggest smoking and alcohol drinking behaviors before a diagnosis of GC are weakly associated with GC survival. Nevertheless, the effect of smoking behavior on prognosis appears to depend on the histological type of GC.
키워드
Stomach neoplasms; Survival; Smoking; Drinking; Prospective studies
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