아시아 의사들의 바이오시밀러 단일 클론 항체에 대한 지식과 관점: 유럽 의사들과 비교
Knowledge and Viewpoints on Biosimilar Monoclonal Antibodies among Asian Physicians: Comparison with European Physicians
박수경, 문원, 김은수, 박상현, 박동일,
소속 상세정보
박수경 ( Park Soo-Kyung )
성균관대학교 의과대학 강북삼성병원 소화기내과
문원 ( Moon Won )
고신대학교 의과대학 내과학교실
김은수 ( Kim Eun-Soo )
경북대학교 의과대학 소화기내과학교실
박상현 ( Park Sang-Hyun )
성균관대학교 의과대학 강북삼성병원 소화기내과
박동일 ( Park Dong-Il )
성균관대학교 의과대학 강북삼성병원 소화기내과
Abstract
Background/Aims: Current knowledge and viewpoints regarding biosimilars among physicians in Asia are unknown, even though these were investigated by European Crohn’s and Colitis Organization (ECCO) members in 2013 and 2015. Thus, this study conducted a multinational survey to assess the awareness of biosimilar monoclonal antibodies among Asian physicians.
Methods: A 17-question multiple-choice anonymous web survey was conducted with the logistic support of the Asian Organization of Crohn’s and Colitis (AOCC). Randomly selected AOCC members were invited by e-mail to participate between February 24, 2017 and March 26, 2017.
Results: In total, 151 physicians from eight Asian countries responded to the survey. Most of the participants were gastroenterologists (96.6%), and 77.5% had cared for inflammatory bowel diseases (IBD) patients for more than 5 years. The majority of the respondents (66.2%) were aware that a biosimilar is similar but not equivalent to the originator. The majority of respondents (77.5%) considered cost saving to be the main advantage of biosimilars, but a high percentage of respondents (38.4%) were concerned about a different immunogenicity from that of the originator (92.4% and 27.1% respectively in ECCO 2015). Only 19.2% considered that the originator and biosimilars were interchangeable, and only 6.0% felt very confident in the use of biosimilars (44.4% and 28.8% respectively in ECCO 2015).
Conclusions: Asian gastroenterologists in 2017 are generally well informed about biosimilars. On the other hand, compared to the ECCO members surveyed in 2015, Asian gastroenterologists had more concerns and less confidence about the use of biosimilars in clinical practice. Thus, IBD-specific data on the comparison of the efficacy, safety, and immunogenicity in Asian patients are needed.
키워드
Biosimilar pharmaceuticals; Infliximab; Asia
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