비만과 췌장담도 질환
Obesity and Pancreatobiliary Disease
이훈구, 고동희,
소속 상세정보
이훈구 ( Lee Hoon-Goo )
Hallym University Dongtan Sacred Heart Hospital Department of Internal Medicine
고동희 ( Koh Dong-Hee )
Hallym University Dongtan Sacred Heart Hospital Department of Internal Medicine
Abstract
Obesity has become a major medical and public health problem worldwide. Recent studies have shown that obesity is a chronic disease that is associated with many diseases, such as gallstone disease, acute pancreatitis, fatty liver, and digestive cancer. Obesity is also a risk factor for the formation of cholesterol gallstones. Clinical and epidemiological studies have suggested that obesity is positively associated with the risk of gallbladder cancer. Obesity may modulate the lipid and endogenous hormones metabolism, affect gallbladder motility, increase the risk of gallstones, and increased the risk of gallbladder cancer. In addition, obesity has been considered a risk factor for pancreatic diseases, including pancreatitis and pancreatic cancer. Obese patients develop systemic and local complications of acute pancreatitis more frequently. Several epidemiologic studies have suggested an association of pancreatic cancer with high body mass and lack of physical activity. This study reviewed the literature on obesity and pancreatobiliary disease in terms of epidemiology and mechanism.
키워드
Obesity; Gallstones; Gallbladder cancer; Acute pancreatitis; Pancreatic cancer
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