HBsAg 소실 후 경구 핵산유사체를 중단한 만성 B형간염의 혈청 재양전 및 급성 악화
Seroreversion and Acute Decompensation in Chronic Hepatitis B after Discontinuation of Oral Nucleotide Analog in the Patients Achieving HBsAg Loss
조혜정, 신승각, 권오상, 김주현, 김연수,
소속 상세정보
조혜정 ( Cho Hye-Jeong )
Gachon University Gil Medical Center Department of Internal Medicine
신승각 ( Shin Seung-Kak )
Gachon University Gil Medical Center Department of Internal Medicine
권오상 ( Kwon Oh-Sang )
Gachon University Gil Medical Center Department of Internal Medicine
김주현 ( Kim Ju-Hyun )
Gachon University Gil Medical Center Department of Internal Medicine
김연수 ( Kim Yun-Soo )
Gachon University Gil Medical Center Department of Internal Medicine
Abstract
Although rare patients with chronic hepatitis B can achieve HBsAg loss on oral nucleos(t)ide analog (NA), the optimal timing of stopping oral NAs safely has been considered when HBsAg and HBV DNA are negative in the serum because HBsAg loss induced by nucleos(t)ide analogs (NAs) appears to be durable if immunosuppressive therapy or chemotherapy are not done. On the other hand, the author experienced a case of HBsAg seroreversion and acute decompensation after the discontinuation of NA in a patient with HBsAg loss. This rare case highlights the need for the close monitoring of patients who achieved HBsAg loss and stopped NA.
키워드
Hepatitis B virus; Functional cure; HBsAg loss; HBsAg reversion; Nucleos(t)ide analogues
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