점액성 위선암과 비점액성 위선암 및 위반지세포암종의 임상적 비교
Clinical Outcomes of Mucinous Gastric Carcinomas Compared with Non-mucinous and Signet Ring Cell Carcinomas
안홍근, 정우철, 김연지, 유성열, 임은선,
소속 상세정보
안홍근 ( Ahn Hong-Geun )
Catholic University College of Medicine St. Vincent’s Hospital Department of Internal Medicine
정우철 ( Chung Woo-Chul )
Catholic University College of Medicine St. Vincent’s Hospital Department of Internal Medicine
김연지 ( Kim Yeon-Ji )
Catholic University College of Medicine St. Vincent’s Hospital Department of Internal Medicine
유성열 ( Ryu Seong-Yul )
Catholic University College of Medicine St. Vincent’s Hospital Department of Internal Medicine
임은선 ( Lim Eun-Sun )
Catholic University College of Medicine St. Vincent’s Hospital Department of Internal Medicine
Abstract
Background/Aims: This study examined the clinical features and prognosis of patients with mucinous gastric carcinoma (MGC), non-mucinous gastric carcinoma (NMGC), and signet ring cell gastric carcinoma (SRC).
Methods: A retrospective cohort study was performed, enrolling 65 patients with MGC from January 2007 to December 2016. During the same period, 1,814 patients with histologically proven gastric cancers underwent curative or palliative operations. One hundred and ninety-five NMGC patients were selected as the 1:3 age- and sex-matched control groups. In addition, 200 SRC patients were identified. This study evaluated the demographic features of the patients, pathologic features of the tumor, and the predictive factors, such as the recurrence-free survival and overall survival.
Results: The recurrence rates were significantly high in MGC than in NMGC or SRC (both p<0.01). The proportion of early gastric cancer was lower in the MGC group than in the other groups (p<0.01). In addition, metastatic lymph nodes were found more frequently in the MGC group (p<0.01), and the proportion of initial pT4, M1 stage, was highest in the MGC group. The recurrence-free survival and overall survival in the MGC group were significantly lower than those in the NMGC or SRC. Subgroup analysis showed that patients with the same American Joint Committee on Cancer (AJCC) stage of each cancer group showed a similar prognosis.
Conclusions: MGC frequently presents an advanced stage with an unfavorable prognosis compared to NMGC or SRC. On the other hand, MGC of the same AJCC stage had a similar prognosis to NMGC and SRC.
키워드
Stomach neoplasms; Mucins; Prognosis
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