Drawing a line between histone demethylase KDM5A and KDM5B: their roles in development and tumorigenesis
유정, 김고운, 전유현, 김지윤, 이상우, 권소희,
소속 상세정보
유정 ( Yoo Jung )
Yonsei University College of Pharmacy
김고운 ( Kim Go-Woon )
Yonsei University College of Pharmacy
전유현 ( Jeon Yu-Hyun )
Yonsei University College of Pharmacy
김지윤 ( Kim Ji-Yoon )
Yonsei University College of Pharmacy
이상우 ( Lee Sang-Wu )
Yonsei University College of Pharmacy
권소희 ( Kwon So-Hee )
Yonsei University College of Pharmacy
Abstract
Distinct epigenetic modifiers ensure coordinated control over genes that govern a myriad of cellular processes. Growing evidence shows that dynamic regulation of histone methylation is critical for almost all stages of development. Notably, the KDM5 subfamily of histone lysine-specific demethylases plays essential roles in the proper development and differentiation of tissues, and aberrant regulation of KDM5 proteins during development can lead to chronic developmental defects and even cancer. In this review, we adopt a unique perspective regarding the context-dependent roles of KDM5A and KDM5B in development and tumorigenesis. It is well known that these two proteins show a high degree of sequence homology, with overlapping functions. However, we provide deeper insights into their substrate specificity and distinctive function in gene regulation that at times divert from each other. We also highlight both the possibility of targeting KDM5A and KDM5B to improve cancer treatment and the limitations that must be overcome to increase the efficacy of current drugs.
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SCI(E)
MEDLINE
KCI
KoreaMed
KAMS