Gender-specific Effect of Micronutrient on Non-erosive Reflux Disease and Erosive Esophagitis
남수연, 박범준, 조영아, 유금혜,
소속 상세정보
남수연 ( Nam Su-Youn )
Kyungpook National University Hospital Department of Internal Medicine
박범준 ( Park Bum-Joon )
National Cancer Center Department of Internal Medicine
조영아 ( Cho Yeong-Ah )
National Cancer Center Department of Clinical Nutrition
유금혜 ( Ryu Kum-Hei )
National Cancer Center Department of Internal Medicine
Abstract
Background/Aims: The effect of dietary micronutrients on non-erosive reflux disease (NERD) and reflux esophagitis is unclear. We aim to evaluate the gender-specific effect of micronutrient on erosive esophagitis and NERD.
Methods: A total of 11 690 participants underwent endoscopy and completed 3-day recordings for dietary intake and questionnaires for reflux symptoms from 2004 to 2008. To evaluate the effect of dietary micronutrients on NERD or erosive esophagitis, adjusted regression analysis with odds ratio (OR) and 95% confidence interval (CI) was used. In addition, we performed gender-specific analysis.
Results: Prevalence of NERD and erosive esophagitis was 6.8% and 11.2% in men and 9.1% and 2.4% in women. In adjusted analysis, high intake of vitamin A (OR, 0.78; 95% CI, 0.64?0.96), retinol (OR, 0.73; 95% CI, 0.59?0.90), vitamin B2 (OR, 0.68; 95% CI, 0.54?0.87), vitamin B6 (OR, 0.75; 95% CI, 0.58?0.96), folic acid (OR, 0.77; 95% CI, 0.62?0.96), calcium (OR, 0.66; 95% CI, 0.53?0.82), and iron (OR, 0.68; 95% CI, 0.53?0.87) had an inverse association with NERD. However, erosive esophagitis has no relationship with micronutrients except vitamin C (OR, 0.78; 95% CI, 0.62?0.98). High dietary intake of calcium reduced the risk of NERD in men and high dietary intake of many micronutrients reduced NERD in women.
Conclusions: While many dietary micronutrients reduced NERD, they had no effect on erosive esophagitis. The effect of micronutrient on NERD was more prominent in women than men.
키워드
Esophagitis; Gender identity; Micronutrients; Non-erosive reflux disease
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