Association Between Gastric Emptying Time and Incidence of Cardiovascular Diseases in Subjects With Diabetes
박형민, 박선영, 정진욱, 조동혁, 박창환, 김현수, 정동진, 최성규, 류종선, 정민영,
소속 상세정보
박형민 ( Park Hyung-Min )
Chonnam National University Medical School Department of Internal Medicine
박선영 ( Park Seon-Young )
Chonnam National University Medical School Department of Internal Medicine
정진욱 ( Chung Jin-Ook )
Chonnam National University Medical School Department of Internal Medicine
조동혁 ( Cho Dong-Hyuk )
Chonnam National University Medical School Department of Internal Medicine
박창환 ( Park Chang-Hwan )
Chonnam National University Medical School Department of Internal Medicine
김현수 ( Kim Hyun-Soo )
Chonnam National University Medical School Department of Internal Medicine
정동진 ( Chung Dong-Jin )
Chonnam National University Medical School Department of Internal Medicine
최성규 ( Choi Sung-Kyu )
Chonnam National University Medical School Department of Internal Medicine
류종선 ( Rew Jong-Sun )
Chonnam National University Medical School Department of Internal Medicine
정민영 ( Chung Min-Young )
Chonnam National University Medical School Department of Internal Medicine
Abstract
Background/Aims: Delayed gastric emptying (GE) is associated with high morbidity and mortality in subjects with diabetes. The aim of this study is to investigate associations between GE time and the major cardiovascular events (coronary heart diseases and ischemic stroke) in diabetic subjects with upper gastrointestinal (UGI) symptoms.
Methods: Among 259 subjects with chronic UGI symptoms who underwent gastric emptying study (GES) over 13 years, 122 diabetic subjects without gastric surgery and/or rapid GE were enrolled in this study. We also gathered data about baseline demographics, clinical characteristics, estimated GE half-time (GE T½) and incidence of cardiovascular events following GES.
Results: The mean age of subjects was 64.0 ± 17.4 years. There were 86 women and 104 subjects with type 2 diabetes. There were 52 (42.6%) subjects with normal GE, 50 (41.0.%) subjects with mild delayed GE, and 20 (16.4%) subjects with marked delayed GE. During follow-up (median, 207 weeks), cardiovascular events occurred in 7 (13.5%) subjects with normal GE, 4 (8.0%) subjects with mild delayed GE and 7 (35.0%) subjects with marked GE ( P = 0.015). Univariate analysis showed that GE T½ was significantly associated with incidence of cardiovascular events (crude OR, 1.74; 95% CI, 1.12-2.69; P = 0.014). In a multivariate model, association between GE T½ and incidence of cardiovascular events remained statistically significant after adjustment for baseline characteristics and comorbidities (adjusted OR, 1.94; 95% CI, 1.21-3.12; P = 0.006).
Conclusion: A delay of GE was associated with an increased incidence of cardiovascular events in diabetic subjects with chronic UGI symptoms.
키워드
Coronary disease; Diabetes Mellitus; Emptying, gastric; Stroke
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