Çе¿±â ¾Æµ¿¿¡¼ AÇü ¹× BÇü °£¿°ÀÇ Ç÷ûÇÐÀû ¿ªÇÐÁ¶»ç -1998³â ÇöÀç ¼¿ï ÀϺÎÁö¿ªÀ» ´ë»óÀ¸·Î-
Seroepidemiology of Hepatitis A and Hepatitis B in Korean Children
°íÀ缺, ¹è¼±È¯, Á¤Áرâ, ¼Á¤±â, Á¤ÁÖ¿µ,
¼Ò¼Ó »ó¼¼Á¤º¸
°íÀ缺 ( Ko Jae-Sung )
¼¿ï´ëÇб³ ÀÇ°ú´ëÇÐ ¼Ò¾Æ°úÇб³½Ç
¹è¼±È¯ ( Bae Sun-Hwan )
¼¿ï´ëÇб³ ÀÇ°ú´ëÇÐ ¼Ò¾Æ°úÇб³½Ç
Á¤Áرâ ( Chung June-Key )
¼¿ï´ëÇб³ ÀÇ°ú´ëÇÐ ÇÙÀÇÇб³½Ç
¼Á¤±â ( Seo Jeong-Kee )
¼¿ï´ëÇб³ ÀÇ°ú´ëÇÐ ¼Ò¾Æ°úÇб³½Ç
Á¤ÁÖ¿µ ( Chung Ju-Young )
¼¿ï´ëÇб³ ÀÇ°ú´ëÇÐ ¼Ò¾Æ°úÇб³½Ç
KMID : 0816119990020010040
Abstract
¸ñÀû : 1998³â Çе¿±â ¼Ò¾Æ¿¡¼ anti-HAVº¸À¯À²°ú HBsAg, anti-HBsÀÇ º¸À¯À²À» Á¶»çÇÏ
°íÀÚ º» ¿¬±¸¸¦ ½ÃÇàÇÏ¿´´Ù.
¹æ¹ý : ¼¿ïÁö¿ªÀÇ ÇÑ ÃʵîÇб³¿¡¼ 6¡12¼¼ÀÇ Çлý 801¸íÀ» ´ë»óÀ¸·Î anti-HAV,
HBsAg, anti-HBs, anti-HBc IgG¸¦ radioimmunoassay¹ýÀ¸·Î °Ë»çÇÏ¿´´Ù.
°á°ú : Àüü 801¸í Áß anti-HAV º¸À¯À²Àº 0%À̾ú´Ù. HBsAg ¾ç¼ºÀº 801¸í Áß 3¸í(0.4%)
À̾ú´Ù. anti-HBs ¾ç¼ºÀº 495¸í(61.8%)À̾ú´Ù. ¿¬·Éº°·Î´Â 6¼¼ 60.7%, 7¼¼ 60.0%, 8¼¼
53.7%, 9¼¼ 68.1%, 10¼¼ 59.3%, 11¼¼ 69.0%À̾ú´Ù. anti-HBs ¾ç¼ºÀÚ Áß 2¸í(0.4%)ÀÌ
anti-HBc ¾ç¼ºÀ¸·Î ³ª¿Í anti-HBs ¾ç¼ºÀÇ ´ëºÎºÐÀº ¿¹¹æÁ¢Á¾¿¡ ÀÇÇØ »ý±ä °ÍÀ¸·Î »ý°¢ÇÑ
´Ù. BÇü °£¿° ¹é½ÅÀ» Á¢Á¾¹ÞÀº ¾Æµ¿Àº 658¸íÀ¸·Î ¿¹¹æ Á¢Á¾·üÀº 82.1%À̾ú´Ù.
°á·Ð : ¼Ò¾Æ¿¡¼ AÇü °£¿° Ç×üÀÇ ÀÚ¿¬ ȹµæÀÌ °ÅÀÇ ¾ø´Â »óÅ¿¡¼ û¼Ò³â°ú ¼ºÀο¡¼ A
Çü °£¿°ÀÇ Áý´Ü ¹ßº´ÀÌ ÀϾ °¡´É¼ºÀÌ ÀÖ´Ù. ¼Ò¾Æ¿¡¼ BÇü °£¿° ¿¹¹æÁ¢Á¾ÀÌ ½Ç½ÃµÈ °á°ú
·Î ¼Ò¾Æ¿¡¼ BÇü °£¿° Ç׿ø º¸À¯À²Àº °¨¼ÒÇÏ°í Ç×ü º¸À¯À²Àº Áõ°¡ÇÏ°í ÀÖ´Ù.
Purpose: The aim of this study is to investigate the seroepidemiology of hepatitis A
and hepatitis B in Korean children.
Methods: 801 children aged 6 to 12 years were enrolled. IgG antibody to hepatitis A
virus (anti-HAV), hepatitis B surface antigen (HBsAg), antibody to HBsAg (anti-HBs),
and IgG antibody to HBc (anti-HBc) were measured by radioimmunoassay.
Results: Of the 801 children, the seroprevalence of anti-HAV was 0%. Three (0.4%)
were seropositive for HBsAg. The seroprevalence of anti-HBs was 61.8%. Two (0.4%)
of 495 anti-HBs positive subjects were positive for anti-HBc. Of the 801 children, 658
(82.1%) had received hepatitis B vaccination.
Conclusions: Since natural anti-HAV is not acquired in the childhood, the outbreak of
hepatitis A is possible in adolescents and young adults. The decrease in seroprevalence
of HBsAg and the increase in seroprevalence of anti-HBs might result from hepatitis B
vaccination program in childhood.
Å°¿öµå
Hepatitis A; Hepatitis B; Seroepidemiology; Children;
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