상부 위장관 증세가 있는 소아의 위십이지장병변 및 Helicobacter pylori 감염
Helicobacter pylori Infection and Gastroduodenal Pathology in Children with Upper Gastrointestinal Symptoms
윤영란, 김미령, 임재영, 최명범, 박찬후, 우향옥, 윤희상, 고경혁, 강형련, 백승철, 이우곤, 조명제, 이광호,
소속 상세정보
윤영란 ( Yoon Young-Ran )
경상대학교 의과대학 소아과학교실
김미령 ( Kim Mi-Ryeung )
경상대학교 의과대학 소아과학교실
임재영 ( Lim Jae-Young )
경상대학교 의과대학 소아과학교실
최명범 ( Choi Myoung-Bum )
경상대학교 의과대학 소아과학교실
박찬후 ( Park Chan-Hoo )
경상대학교 의과대학 소아과학교실
우향옥 ( Woo Hyang-Ok )
경상대학교 의과대학 소아과학교실
윤희상 ( Youn Hee-Sang )
경상대학교 의과대학 소아과학교실
고경혁 ( Ko Gyung-Hyuck )
경상대학교 의과대학 병리학교실
강형련 ( Kang Hyung-Lyun )
경상대학교 의과대학 미생물학교실
백승철 ( Baik Seung-Chul )
경상대학교 의과대학 미생물학교실
이우곤 ( Lee Woo-Kon )
경상대학교 의과대학 미생물학교실
조명제 ( Cho Myung-Je )
경상대학교 의과대학 미생물학교실
이광호 ( Rhee Kwang-Ho )
경상대학교 의과대학 미생물학교실
KMID : 0816120030060020103
Abstract
Purpose: This study was undertaken to evaluate the gastroduodenal pathology and Helicobacter pylori infection in children with upper gastrointestinal symptoms.
Methods: One hundred and seven pediatric patients with upper gastrointestinal symptoms were undergone endoscopy at the Gyeongsang National University Hospital from June 1990 to April 1991. Histopathologic examination was done by H & E staining of gastric antral biopsy specimen and gastritis was defined according to the Sydney System. Tissue H. pylori status was evaluated with the urease test using Christensen´s urea broth and H & E or Warthin-Starry silver staining of gastric antral biopsy specimen. IgG Immunoblotting were also performed to detect specific anti-H. pylori antibody in these patients.
Results: The reasons for endoscopy were recurrent abdominal pain, acute abdominal pain, sallow face, hunger pain, and frequent nausea. Variable degrees of gastric mucosal hyperemia were found in most of the patients. Gastric hemorrhagic spots, gastric ulcer, duodenal ulcer, duodenal erosion, and hemorrhagic duodenitis were rare endoscopic findings. Histologic chronic gastritis was found in 88% of ´107 patients. Histologic chronic duodenitis was observed in all 99 patients whose tissue were available. Gastric tissue H. pylori was positive in 57% of 107 patients by one of the ureasetest, H & E staining and Warthin-Starry silver staining. However, gastric tissue H. pylori detection rate was lower in the younger age groups. Anti-H. pylori IgG antibodies were detectable in 96% of 107 patients.
Conclusion: Chronic gastroduodenitis and anti-H. pylori IgG antibody were ubiquitous in children with upper gastrointestinal symptoms.
키워드
Helicobacter pylori;Urease test;Immunoblotting;Gastritis;Child
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