소아 만성 B형 간염 환아에서 Interferon- α의 용량 차이 및 재치료에 따른 치료 효과 비교
The Comparison of Interferon-α Treatment by Dosages and Retreatment for Chronic Hepatitis B in Children
장창환, 이경희, 황위경, 오기원, 박우생, 이준화, 고철우, 최병호,
소속 상세정보
장창환 ( Jang Chang-Hwan )
경북대학교 의과대학 소아과학교실
이경희 ( Lee Kyung-Hee )
경북대학교 의과대학 소아과학교실
황위경 ( Hwang Wi-Kyung )
경북대학교 의과대학 소아과학교실
오기원 ( Oh Ki-Won )
경북대학교 의과대학 소아과학교실
박우생 ( Park Woo-Saeng )
경북대학교 의과대학 소아과학교실
이준화 ( Lee Jun-Hwa )
경북대학교 의과대학 소아과학교실
고철우 ( Ko Cheol-Woo )
경북대학교 의과대학 소아과학교실
최병호 ( Choe Byung-Ho )
경북대학교 의과대학 소아과학교실
KMID : 0816120030060020152
Abstract
Purpose: We compared the therapeutic efficacy of low dose with that of standard dose of interferon (IFN) treatment and also compared the first IFN treatment with retreattent.
Methods: We have studied 51 children (age, 2 ~14) treated for chronic hepatitis B from March 1990 to August 1999. Twenty seven children had been treated with 3 MU/m² (2.66±0.66 MU/m²) of IFN- α three times a week for 6 months (range, 6 ~12 months), whereas 24 children with 6 MU/m² (4.45±0.94 MU/m²). There was no significant difference in gender, age, initial ALT and HBV DNA levels between each comparative group.
Results: Among the 27 children treated with 3 MU/m² of IFN, ALT level had normalized in 11 children (41%) and anti-HBe seroconversion occurred in 9 children (33%) one year after the initiation of treatment. In comparison, among the 24 children treated with 6 MU/m2 of IFN, ALT normalized in 12 children (50%) and anti-HBe seroconversion occurred in 7 children (29%). In comparing the first treatment group to retreatment group, ALT level had normalized in 23 children (45%) and anti-HBe seroconversion occurred in 16 children (31%) among the 51 children treated with the first course of IFN treatment. In comparison, ALT normalized and anti-HBe seroconversion occurred in 3 children (25%) among the retreated 12 children.
Conclusion: There was no significant difference in the therapeutic efficacies between 3 MU/m² and 6 MU/m² dose of IFN treated groups in ALT normalization and anti-HBe seroconversion. The retreatment efficacy of IFN- a was as effective as the first treatment.
키워드
Chronic hepatitis B;Interferon;Treatment;Children
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