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Hypocalcemic Tetany in a 13-Year-Old Girl with Wilson’s Disease
라채익, 김상용, 고홍,
소속 상세정보
라채익 ( Ra Chae-Ik )
연세대학교 의과대학 소아과학교실
김상용 ( Kim Sang-Yong )
연세대학교 의과대학 소아과학교실
고홍 ( Koh Hong )
연세대학교 의과대학 소아과학교실
KMID : 0816120110140010086
Abstract
Wilson’s disease is an autosomal recessive disorder marked by disruptions in copper metabolism which leads to accumulation of copper in the liver, brain, cornea, and other tissues. Manifestations of this disease are more likely to be hepatic during early childhood and neurologic in adolescent. In addition, abnormalities that develop during disease progression may result in other manifestations such as hematologic, endocrine, or renal findings. Here we report a 13-year-old girl who presented with hypocalcemic tetany shortly after being diagnosed with Wilson’s disease. Despite aggressive calcium, magnesium, and vitamin D replacement therapy, the hypocalcemia and hypomagnesemia did not promptly respond. Mineral levels in the blood took longer than 3 weeks to normalize. We speculate that a parathyroid insufficiency and disrupted vitamin D metabolism caused by copper accumulation and hepatic dysfunction resulted in hypocalcemic tetany.
키워드
Wilson’s disease; Hypoparathyroidism; Hypocalcemic tetany; Vitamin D deficiency
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