한국 청소년의 HOMA-IR과 대사 위험 요소와의 연관성
HOMA-IR and Its Association with Metabolic Risk Factors among Korean Adolescents
서유진, 이선근, 김신혜, 박미정,
소속 상세정보
서유진 ( Seo Yoo-Jin )
인제대학교 의과대학 상계백병원 소아청소년과
이선근 ( Lee Sun-Gun )
인제대학교 의과대학 상계백병원 소아청소년과
김신혜 ( Kim Shin-Hye )
인제대학교 의과대학 상계백병원 소아청소년과
박미정 ( Park Mi-Jung )
인제대학교 의과대학 상계백병원 소아청소년과학교실
KMID : 0816120110140040376
Abstract
Purpose: This study was performed to evaluate the distribution of homeostasis model assessment of insulin resistance (HOMA-IR), a surrogate marker of insulin resistance, and its association with metabolic risk factors among Korean adolescents.
Methods: This study was based on data from Korean National Health and Nutrition Examination Survey (KNHANES) 2008∼2009. Data from 2,035 adolescents (1,053 boys, 982 girls; aged 10∼19 years) were analyzed. We classified all subjects into four groups, based on the quartiles of HOMA-IR, and the highest quartile group was defined as the group with insulin resistance. We performed multivariate logistic regression analysis to determine the independent risk factors for insulin resistance.
Results: The highest quartile values of HOMA-IR representing insulin resistance were 3.4 for boys and 3.6 for girls. Mean body mass index, waist circumference, systolic blood pressure, serum triglyceride, alanine aminotransferase (ALT), fasting glucose and insulin increased, whereas HDL cholesterol decreased with increased HOMA-IR. We found HOMA-IR has significant positive correlation with waist circumference, triglyceride, ALT level and systolic/diastolic blood pressure, while it has negative correlation with HDL-cholesterol level (p＜0.005). Independent predictors (odds ratio) for insulin resistance were elevated ALT (3.53 for boys; 4.04 for girls), central obesity (3.01 for boys; 3.20 for girls), and hypertriglyceridemia (3.03 for boys; 1.94 for girls).
Conclusion: Metabolic risk factors were strongly associated with insulin resistance, defined as highest quartile values of HOMA-IR (≥3.4 for boys and ≥3.6 for girls). These values could be useful as a marker of insulin resistance and metabolic risk in Korean adolescents.
키워드
Adolescent;Insulin resistance;Metabolic profile;Metabolic syndrome
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