Biological Therapy for Inflammatory Bowel Disease in Children
나소영, 심정옥,
소속 상세정보
나소영 ( Na So-Young )
동국대학교 의과대학 소아과학교실
심정옥 ( Shim Jung-Ok )
고려대학교 의과대학 소아과학교실
KMID : 0816120120150010013
Abstract
The pathogenesis of inflammatory bowel diseases is not very well understood; it is currently thought to be caused by the interaction between genetic factors, environmental factors, intestinal microbes, and immune factors. Biological agents such as anti-tumor necrosis factor (anti-TNF) are widely being used as therapeutic agents. Infliximab, a chimeric monoclonal IgG1 antibody against tumor necrosis factor, has been demonstrated to have an effect in the induction and maintenance of remission in Crohn’s disease in children. The effects of biological agents, typified by anti-TNFs, in inflammatory bowel disease in children; the recent concern on the administration of biological agents in combination with immunomodulators; and ’Top-down’ therapy are some of the topics covered in this review.
키워드
Inflammatory bowel disease; Infliximab; Children
원문 및 링크아웃 정보
등재저널 정보