The Role of Inflammatory Mediators in the Pathogenesis of Nonalcoholic Fatty Liver Disease
김준성,
소속 상세정보
김준성 ( Kim Joon-Sung )
울산대학교 의과대학 울산대학교병원 소아과학교실
KMID : 0816120120150020074
Abstract
With a markedly increased prevalence of obesity, non-alcoholic fatty liver disease (NAFLD) now becomes the most common cause of chronic liver disease in both adults and children. The etiology and pathogenesis of NAFLD are multifactorial and remain incompletely understood. According to the "two-hit" theory, inflammatory cytokines and adipokines are activated by oxidative stress and they are involved in insulin resistance, necroinflammatory steatohepatitis and fibrosis. This review discusses the latest updates on the role of some of important inflammatory adipokines and cytokines in the pathogenesis of NAFLD with an emphasis on their potential therapeutic implications.
키워드
Nonalcoholic fatty liver disease; Obesity; Inflammation; Adipokine; Cytokine; Pathogenesis; Insulin resistance
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