Leptin, Neuropeptide Y and Islet Amyloid Polypeptide Levels in Obese Children
최민선, 지수희, 김은영, Moon Kyung-Rae,
소속 상세정보
최민선 ( Choi Min-Seon )
Chosun University School of Medicine Department of Pediatrics
지수희 ( Jee Soo-Hee )
Chosun University School of Medicine Department of Pediatrics
김은영 ( Kim Eun-Young )
Chosun University School of Medicine Department of Pediatrics
( Moon Kyung-Rae )
Chosun University School of Medicine Department of Pediatrics
KMID : 0816120120150030166
Abstract
Purpose: The aim of this study was to compare serum leptin, neuropeptide Y (NPY), and islet amyloid polypeptide (amylin) levels in obese and normal weight children, and to investigate their correlations with anthropometric parameters and metabolic bio-marker levels.
Methods: Body mass index (BMI), waist and hip circumference, blood pressure (systolic/diastolic), lipid profile, fasting glucose, and serum insulin, leptin, NPY, and amylin levels were measured in 56 children (24 obese children and 32 non-obese controls). Homeostatic model assessment-insulin resistance (HOMA-IR) values were calculated and the relationships between anthropometric variables, metabolic biomarkers, and diet-regulating factors (leptin, NPY, and amylin levels) were examined.
Results: BMI, hip circumference, waist circumference, and systolic and diastolic pressure were significantly higher in the obese group than in the non-obese group (p＜0.0001). Total cholesterol, triglyceride, low-density lipoprotein -cholesterol, glucose, and insulin levels were also significantly higher in the obese group (p＜0.05). On the other hand, high-density lipoprotein-cholesterol levels were higher in the non-obese group , but this was not significant. Serum leptin, NPY, and amylin levels were significantly higher in the obese group (p＜0.05). Furthermore, in the obese group, leptin levels were found to be significantly correlated with BMI (r=0.379, p=0.043), and NPY levels (r=0.377, p=0.044), and amylin levels were found to be significantly correlated with insulin levels (r=0.400, p=0.048), and HOMA-IR (r=0.459, p=0.028).
Conclusion: Metabolic risk factor alterations are present in obese children, and these children show abnormalities in the diet regulatory system caused by leptin, NPY, and amylin resistance. Of particular note, amylin was found to be positively correlated with insulin resistance.
키워드
Leptin; Neuropeptide Y; Islet amyloid polypeptide; Childhood obesity
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