Influencing Factors to Results of the Urease Test: Age, Sampling Site, Histopathologic Findings, and Density of Helicobacter pylori
서지현, 윤희상, 염정숙, 박지숙, 전진수, 임재영, 박찬후, 우향옥, 박정제, 고경혁, 백승철, 이우곤, 조명제, 이광호,
소속 상세정보
서지현 ( Seo Ji-Hyun )
Gyeongsang National University School of Medicine Department of Pediatrics
윤희상 ( Youn Hee-Shang )
Gyeongsang National University School of Medicine Department of Pediatrics
염정숙 ( Yeom Jung-Sook )
Gyeongsang National University School of Medicine Department of Pediatrics
박지숙 ( Park Ji-Sook )
Gyeongsang National University School of Medicine Department of Pediatrics
전진수 ( Jun Jin-Su )
Gyeongsang National University School of Medicine Department of Pediatrics
임재영 ( Lim Jae-Young )
Gyeongsang National University School of Medicine Department of Pediatrics
박찬후 ( Park Chan-Hoo )
Gyeongsang National University School of Medicine Department of Pediatrics
우향옥 ( Woo Hyang-Ok )
Gyeongsang National University School of Medicine Department of Pediatrics
박정제 ( Park Jung-Je )
Gyeongsang National University School of Medicine Department of Otolaryngology
고경혁 ( Ko Gyung-Hyuck )
Gyeongsang National University School of Medicine Department of Pathology
백승철 ( Baik Seung-Chul )
Gyeongsang National University School of Medicine Department of Microbiology
이우곤 ( Lee Woo-Kon )
Gyeongsang National University School of Medicine Department of Microbiology
조명제 ( Cho Myung-Je )
Gyeongsang National University School of Medicine Department of Microbiology
이광호 ( Rhee Kwang-Ho )
Gyeongsang National University School of Medicine Department of Microbiology
KMID : 0816120130160010034
Abstract
Purpose: We investigated the positivity rate and the time period to the positive color change of the urease test in children and adults and assessed the correlation of the urease test to histopathologic findings.
Methods: From 1995 to 2000, endoscopic biopsies of the antrum and body were collected from 811 children and 224 adults and subjected to urease tests and histopathology.
Results: The positivity rate of the urease test was 49.4% for 0-4 years, 48.4% for 5-9 years, 47.3% for 10-15 years, and 62.5% for 20-29 years in the antrum. The positivity rate was 85.1% in 0-4 years, 82.3% in 5-9 years, 74.7% in 10-15 years, and 74.1% in 20-29 years for the body. In the antrum, the highest positivity rate was ＜1 hour for the group aged 10-29 years and 6-24 hours in the group ＜10 years old (p＜0.0001). In the body, the highest positivity rate was ＜1 hour in adults and 6-24 hours in children (p＜0.0001). The proportions of the positive reactions within 1 hour were similar for the antrum and the body. In the cases of more severe chronic gastritis, active gastritis, and Helicobacter pylori infiltration, a positive urease test reaction occurred more quickly (p＜0.0001).
Conclusion: There were significant differences in urease tests according to age and sampling site. The discrepancy between the antrum and the body was greater in younger children. These results might be related to the low density and patchy distribution of bacteria in children and in the body.
키워드
Urease test;Helicobacter pylori infection;Age;Pathology
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