Current Role of Lamivudine Regarding Therapeutic Response and Resistance in Children with Chronic Hepatitis B
홍석진, 김여향, 최병호, 박효정, 탁원영, 권영오,
소속 상세정보
홍석진 ( Hong Suk-Jin )
Kyungpook National University School of Medicine Department of Pediatrics
김여향 ( Kim Yeo-Hyang )
Kyungpook National University School of Medicine Department of Pediatrics
최병호 ( Choe Byung-Ho )
Kyungpook National University School of Medicine Department of Pediatrics
박효정 ( Park Hyo-Jung )
Kyungpook National University School of Medicine Department of Pediatrics
탁원영 ( Tak Won-Young )
Kyungpook National University School of Medicine Department of Internal Medicine
권영오 ( Kweon Young-Oh )
Kyungpook National University School of Medicine Department of Internal Medicine
KMID : 0816120130160020080
Abstract
Purpose: To identify the predictive factors of long-term therapeutic response or resistance to lamivudine treatment in children and adolescents with chronic hepatitis B.
Methods: Eighty one children and adolescents with chronic hepatitis B were included, who received lamivudine treatment for at least 6 months. Their condition was monitored for at least 12 months (12-88 months) thereafter. Twenty one (25.9%) were preschool children (age≤6). For patients who had developed HBeAg seroconversion or breakthrough, univariate and multivariate analyses were used to identify the effects of age, gender, pretreatment alanine aminotransferase (ALT) and hepatitis B virus DNA levels.
Results: HBeAg seroconversion occurred in 49 (60.5%) of the 81 patients after the initiation of the lamivudine therapy. In 65 patients whom were monitored for over 24 months, the seroconversion rate was significantly higher in younger patients (p=0.040), especially in those patients of preschool age (age≤6, p=0.031). The seroconversion rate was significantly higher in higher pretreatment ALT (p=0.003). The breakthrough occurred in 21 (25.9%) of the 81. The breakthrough rate was lower in younger aged patients (age≤6), and with higher pretreatment ALT levels, but no significant difference.
Conclusion: Younger age is a good predictor of HBeAg seroconversion in children with
키워드
Chronic hepatitis;Child;Lamivudine;Seroconversion;Therapeutics
원문 및 링크아웃 정보
등재저널 정보