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ÀÎü ¹× ÀÎÇü ÆÒÅè¿¡¼­ Àü½Å¹æ»ç¼±Á¶»ç½Ã ¿­Çü±¤¼±·®°è(TLD)¸¦ ÀÌ¿ëÇÑ ¼±·®ºÐÆ÷ ±ÕÀϼº In vive and in vitro Confirmation of Dose Homogeneity in Total Body Irradiation with Thermoluminescent Dosimeter

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1ÁöÀDZÔ/1Eui Kyu Chie 1°­À§»ý/2¹Ú¼®¿ø/1/3±èÀÏÇÑ/1Wee Saing Kang/2Suk Won Park/13Il Han Kim

Abstract

¸ñÀû : ¸é¿ª¾ïÁ¦, ¾Ç¼º¸²ÇÁÁ¾ ¹× ¹éÇ÷º´ÀÇ Ä¡·á, °ñ¼öÀÌ½Ä µî¿¡ Àû¿ëµÇ´Â Àü½Å¹æ»ç¼±Ä¡·á¿¡ ½ÃÇà
µÇ´Â Á¿ì À̹®´ëÇâÁ¶»ç¹ýÀÇ Ç¥¸é ¹æ»ç¼±·® ¹× Á᫐ ¹æ»ç¼±·®ÀÇ ±ÕÀϼºÀ» ¿­Çü±¤¼±·®°è¸¦ ÀÌ¿ëÇÏ
¿© È®ÀÎÇÏ°íÀÚ ÇÏ¿´´Ù.
´ë»ó ¹× ¹æ¹ý : 1996³â 9¿ùºÎÅÍ 1998³â 8¿ù±îÁö Á¿ì À̹®´ëÇâÁ¶»ç¹ýÀ¸·Î Àü½Å¹æ»ç¼±Ä¡·á¸¦ ½Ã
ÇàÇÑ 10¸íÀÇ È¯ÀÚ Áß ¸Å¹ø ¹æ»ç¼±·®ÀÌ ÃøÁ¤µÈ 8¸íÀÇ È¯ÀÚ¸¦ ´ë»óÀ¸·Î ÇÏ¿´´Ù. ¿­Çü±¤¼±·®°è¸¦ »ç
¿ëÇÏ¿© µÎºÎ, °æºÎ, ¾×¿ÍºÎ, ´ëÅðºÎ, Á·°üÀýºÎ µîÀÇ Ç¥¸é ¼±·®À» ÃøÁ¤ÇÏ¿´°í ÀÎÇü ÆÒÅè¿¡¼­ µ¿ÀÏÇÑ
Á¶°ÇÇÏ¿¡¼­ µÎºÎ, °æºÎ, ¾×¿ÍºÎ, º¹ºÎ, µÐºÎ µîÀÇ Ç¥¸é ¼±·®°ú Á᫐ ¼±·®À» ÃøÁ¤ÇÏ¿´´Ù.
°á°ú: Á߽ɺÎÀÎ º¹ºÎ ó¹æ ¼±·®À» ±âÁØÀ¸·Î ÇÒ ¶§ ºÎÀ§º°·Î ȯÀÚÀÇ µÎºÎ, °æºÎ, ¾×¿ÍºÎ, ´ëÅðºÎ,
Á·°üÀýºÎ¿¡¼­ Ç¥¸é ¹æ»ç¼±·®Àº °¢°¢ 91.3¡¾7.8, 98.3¡¾7.5, 95.1¡¾6.3, 98.3¡¾5.5, 95.3¡¾6.3£¥¿´´Ù. ÀÎ
Çü ÆÒÅè¿¡¼­ ó¹æ ¼±·®¿¡ ´ëÇÏ¿© µÎºÎ, °æºÎ, ¾×¿ÍºÎ, º¹ºÎ ¹× µÐºÎ¿¡¼­ÀÇ Ç¥¸é ¹æ»ç¼±·®Àº °¢°¢
85.0¡¾4.0, 86.6¡¾5.8, 83.9¡¾4.9, 94.8¡¾5.3, 94.8¡¾2.8£¥¿´°í, Á᫐ ¹æ»ç¼±·®À» °¢°¢ 96.6¡¾2.2, 95.3¡¾
3.2, 80.4¡¾1.9, 100.0¡¾3.1, 90.5¡¾2.2£¥¿´´Ù. Ç¥¸é ¼±·® ´ëºñ Á᫐ ¼±·®ÀÇ ºñ´Â µÎºÎ, °æºÎ, ¾×¿ÍºÎ
º¹ºÎ ¹× µÐºÎ¿¡¼­ °¢°¢ 1.14¡¾0.06, 1.10¡¾0.09, 0.96¡¾0.05, 1.06¡¾0.06, 0.95¡¾0.02¿´´Ù. ÀÎÇü ÆÒÅè¿¡
¼­ ¾òÀº Ç¥¸é ¼±·® ´ëºñ Á᫐ ¼±·®ÀÇ ºñ¸¦ ÀÌ¿ëÇÏ¿© ȯÀÚ¿¡¼­ÀÇ Á᫐ ¼±·®À» °è»êÇÏ¿´À» ¶§, µÎ
ºÎ, °æºÎ, ¾×¿ÍºÎ, ´ëÅðºÎ, Á·°üÀýºÎ¿¡¼­ °¢°¢ 103.4¡¾9.0, 107.8¡¾10.5, 91.1¡¾6.1, 93.8¡¾4.5, 104.5¡¾
9.3£¥¿´´Ù.
°á·Ð : ȯÀÚ¿¡¼­ÀÇ ÃøÁ¤µÈ Ç¥¸é ¼±·®°ú °è»êÇÑ Á᫐ ¼±·®ÀÇ ºÐÆ÷´Â £­8.9 ¡­ £«7.8£¥¿´À¸³ª, ¼±·®
ºÐÆ÷°¡ £«5£¥ ÀÌ»ó Áõ°¡ ¶Ç´Â °¨¼ÒµÈ ºÎÀ§ÀÎ °æºÎ¿Í ¾×¿ÍºÎ¿¡¼­´Â ÀÎÇü ÆÒÅè°ú ȯÀÚ¿ÍÀÇ ÁÂ¿ì µÎ
²²ÀÇ Â÷ÀÌ¿¡ ÀÇÇؼ­ ½ÇÁ¦º¸´Ù Å©°Ô °è»êµÇ¾úÀ¸¹Ç·Î ½ÇÁ¦ ȯÀÚ¿¡¼­ÀÇ Àü½Å ¼±·® ºÐÆ÷´Â À̺¸´Ù ´õ
¿ì¼öÇÒ °ÍÀ¸·Î »ý°¢µÈ´Ù.

Purpose : Total body irradiation (TBI) or whole body irradiation is used to acquire immune
suppression, to treat malignant lymphoma and leukemia, and as an conditioning regimen for
bone marrow transplantation. For these purposes, many methods were developed to obtain
homogenous dose distribution. The objective of this study was to analyze and confirm the
accuracy and the homogeneity of the treatment setup, the parallel opposed lateral technique,
currently used in Seoul Nation University Hospital.
Materials and Methods : Surface dose data, measured with a thermoluminescent dosimeter,
of 8 patients among 10 patients, who were given total body irradiation with the parallel
opposed lateral technique between September 1996 to August 1998, at Seoul National
University Hospital were analyzed. Surface doses were measured at the head, neck, axilla,
thigh, and ankle level. Surface and midline doses were measured with similar sep-up and
technique in the Humanoid phantom.
Results : Measured surface doses relative to prescribed dose for the head, neck, axilla, thigh,
and ankle level were 91.3¡¾7.8, 98.3¡¾7.5, 95.1¡¾6.3, 98.3¡¾5.5, and 95.3¡¾6.3£¥, respectively. The
midline doses of the head, neck, axilla, thigh, and ankle level estimated from the
surface-to-midline ratios in the Humanoid phantom were 103.4¡¾9.0, 107.8¡¾10.5, 91.1¡¾6.1, 93.8
¡¾4.5, and 104.5¡¾9.3£¥, respectively. Measured surface doses and estimated midline doses
ranged from £­8.9 to £«7.8£¥. Midline doses at the neck and the axilla level deviated more
than 5£¥ from the prescribed doses. The difference of the estimated midline doses at the neck
and the axilla level and the actual doses were attributed to the thickness differences between
the Humanoid phantom and the patients.
Conclusion : Distribution of the midline doses as well as the surface doses were measured
to be within £­8.7 ¡­ £«7.8£¥ range. Actual dose distribution in the patient is expected to be
better than the measured dose range mainly attributed to thickness difference between the
patient and the Humanoid phantom.

Å°¿öµå

Total body irradiation; Thermoluminescent dosimeter; Dose distribution;

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