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Abstract

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Purpose: This is a retrospective study to evaluate the results of radiation therapy in nasopharyngeal carcinoma.
Materials and Methods: From September 1989 to October 1996, 19 patients with
nasopharyngeal carcinoma competed planned radiation therapy course. Stages were ¥° in
2 patients, ¥± in 6, ¥² in 2 ¥³ in 9 patients, respectively. Pathology was squamous cell
carcinoma in 5 patients, undifferentiated cell carcinoma in 14 patients. Fourteen patients
were treated with radiation therapy only. Five patients received chemotherapy The
follow-up period ranged form 5 months to 115 months with a median of 33 months
Follow-up was possible in all patients.
Results: Responses to radiation therapy were complete response in 15 patients, partial
response in 2 and no response in 2, respectively. Patterns of failure were as follows :
locoregional recurrence in 6 patients and distant metastasis in 4 patients. The sites of
distant metastasis were bone, liver and lung. Five year survival rate was 47.8% and
five year disease free survival rate was 48.1%, Stage T-stage, N-stage, central nervous
system involvement, pathology type, performance status, response, radiation dose,
chemotherapy were not significant prognostic factors.
Conclusion: 5-year survival rate was 47.8% and 5-year disease free survival rate was
48.1%. The advances in radiation therapy techniques and chemotherapy are needed.

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ºñÀΰ­¾Ï; ¹æ»ç¼±Ä¡·á; Nasopharyngeal cancer; Radiation therapy;

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