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Multistatic Field ¶Ç´Â 3Â÷¿ø °ø¿ëº¸»óü¸¦ »ç¿ëÇÑ À¯¹æÀÇ ¹æ»ç¼± Á¶»ç¹ýÀÇ Æò°¡ Improved Breast Irradiation Techniques Using Multistatic Fields or Three Dimensional Universal Compensators

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ÇÑ¿µÀÌ/Young Yih Han Á¶ÀçÈ£/¹ÚÈñö/Ãß¼º½Ç/¼­Ã¢¿Á/Jae Ho Cho/Hee Chul Park/Sung Sil Chu/Chang Ok Suh

Abstract

¸ñÀû: À¯¹æº¸Á¸ ¼ö¼ú ÈÄ ÇàÇÏ´Â ¹æ»ç¼±Ä¡·áÀÎ 2¹® ´ëĪÁ¶»ç(two tangential field technique)½Ã ³ªÅ¸³ª´Â ¼±·®ºÐÆ÷ÀÇ ºÒ±ÕÀϼºÀ» È¿°úÀûÀ¸·Î °³¼±Çϱâ À§ÇÏ¿©, multistatic fieldsÀÇ »ç¿ë¹ý°ú °ø¿ëº¸»óü »ç¿ë¹ýÀ» Á¦½ÃÇÏ°í Æò°¡ÇÏ¿´´Ù. ´ë»ó ¹×
¹æ¹ý:

1)
Multistatic field ¹æ¹ý : 3Â÷¿øÀÇ Ä¡·á°èȹ¿ë software (RTP)¸¦ ÀÌ¿ëÇÏ¿©, wedge¸¦ »ç¿ëÇÑ 2¹® ´ëĪ Á¶»çÀÇ ÃÖÀûÀÇ Ä¡·á°èȹÀ» ½ÃÇàÇÑ ÈÄ beam's eye view»ó¿¡¼­ °úÁ¶»ç°¡ ÀϾ´Â ºÎºÐÀ» °¡¸®¿ö ÁÖµµ·Ï blocked field¸¦ ¼³°èÇÏ°í, ±× beam¿¡ ´ëĪµÇ´Â beamÀ»
¸¸µé¾ú´Ù.
±âÁ¸ÀÇ 2°³ÀÇ tangential field¿Í Ãß°¡µÈ fieldÀÇ weightingÀ» ÃÖÀûÀÇ ¼±·®ºÐÆ÷¸¦ °®µµ·Ï Á¶ÀýÇÏ¿´´Ù. 2) °ø¿ëº¸»óü »ç¿ë¹ý : 1999¿Í 2000³â¿¡ º»¿ø¿¡¼­ whole-breast radiotherapy¸¦ ¹ÞÀº ȯÀÚ 20¸íÀÇ À¯¹æÀÇ Å©±â¸¦ ÃøÁ¤ÇÏ°í Æò±ÕÇÏ¿© Ç¥ÁØ À¯¹æ ¸ðµ¨À»
¸¸µé¾ú´Ù.
ÀÌ
¸ðµ¨¿¡ ´ëÇÏ¿© °ø¿ëº¸»óü¸¦ ¼³°èÇÏ°í, ¼³°èµÈ °ø¿ëº¸»óüÀÇ geometry¸¦ RTP¿¡ ÀÔ·ÂÇÑ ÈÄ È¯ÀÚÀÇ Ä¡·á °èȹÀ» ¼öÇàÇÏ¿´´Ù. 2¹® ´ëĪÁ¶»ç Ä¡·á °èȹ°ú, multistatic fieldsÀÇ °æ¿ì ±×¸®°í °ø¿ë º¸»óü¸¦ »ç¿ëÇÑ °æ¿ìÀÇ Ä¡·á°èȹ¿¡¼­ÀÇ ºÒ ±ÕÀϵµ(DII : ó¹æ¼±·®ÀÇ
95-105%¸¦
¹þ¾î³ª´Â PTVÀÇ ºÎÇÇÀÇ ¹éºÐÀ²), ÃÖ´ë¼±·® °ª(Dmax) ±×¸®°í µî°¡¼±·® °î¼±À» °¢°¢ ºñ±³ÇÏ¿´´Ù. °á°ú: Multistatic field ¹æ¹ýÀº DIIÀÇ Æò±Õ°ªÀ» 14.6% (p value<0.000) ³·Ãß°í Dmax¸¦ 4.7% (p value<0.000) ³·ÃãÀ¸·Î½á, ÀüÅëÀûÀÎ 2¹®
´ëĪ
Á¶»ç¹ýº¸´Ù ¿ì¼öÇÑ ¹æ¹ýÀ¸·Î È®ÀεǾú´Ù. ¹Ý¸é¿¡ °ø¿ëº¸»óüÀÇ »ç¿ëÀº Æò±Õ DII¸¦ 3.7% ³·ÃßÁö¸¸(p value=0.260) Æò±Õ Dmax´Â °ÅÀǵ¿ÀÏ ÇÏ¿©(0.3% °¨¼Ò, p value = 0.867), ÀüÅëÀûÀÎ ¹æ¹ýº¸´Ù ¿ì¼ö¼ºÀÌ Å©°Ô´Â ¾ø´Â °ÍÀ¸·Î Æò°¡µÇ¾ú´Ù. ±×·¯³ª ȯÀÚÀÇ
ü°î¼±ÀÌ
º¸»óü¿Í Àß ÀÏÄ¡ÇÏ´Â °æ¿ì¿¡´Â DII°¡ 18% ±îÁö °¨¼ÒÇÏ¿´´Ù. °á·Ð: Multistatic field ¹æ¹ýÀº ¸ðµç ȯÀÚ¿¡ ´ëÇÏ¿© ¼±·®ºÐÆ÷ÀÇ ±ÕÀϼºÀ» Àü¹ÝÀûÀ¸·Î Çâ»ó½ÃÅ°´Â È¿°úÀûÀÎ ¹æ¹ýÀ¸·Î Æò°¡µÇ´Â ¹Ý¸é °ø¿ëº¸»óüÀÇ »ç¿ëÀº º¸»óüÀÇ Å©±â°¡ ȯÀÚÀÇ Ã¼ À±°û°ú Àß
ÀÏÄ¡ÇÏ´Â
°æ¿ì¸¸ È¿°úÀûÀ¸·Î, Àû¿ëÀÇ ¹üÀ§¿¡´Â ÇÑ°è°¡ ÀÖ´Â ¹æ¹ýÀ¸·Î Æò°¡µÇ¾ú´Ù.

Purpose: In order to improve dose homogeneity and to reduce acute toxicity in tangential whole breast radiotherapy, we evaluated two treatment techniques using multiple static fields or universal compensators. Materials and Methods:
1)
Multistatic field technique : Using a three dimensional radiation treatment planning system, Adac Pinnacle 4.0, we accomplished a conventional wedged tangential plan. Examining the isodose distributions, a third field which blocked overdose
regions
was
designed and an opposing field was created by using an automatic function of RTPS. Weighting of the beams was tuned until an ideal dose distribution was obtained. Another pair of beams were added when the dose homogeneity was not satisfactory. 2)
Universal compensator technique : The breast shapes and sizes were obtained from the CT images of 20 patients who received whole breast radiation therapy at our institution. The data obtained were averaged and a pair of universal physical
compensators
were designed for the averaged data. DII (Dose Inhomogeneity Index : percentage volume of PTV outside 95¡­105% of the prescribed dose), Dmax (the maximum point dose in the PTV) and isodose distributions for each technique were compared.
Results:
The multistatic field technique was found to be superior to the conventional technique, reducing the mean value of DII by 14.6% (p value<0.000) and the Dmax by 4.7% (p value<0.000). The universal compensator was not significantly
superior to
the conventional technique since it decreased Dmax by 0.3% (p value=0.867) and reduced DII by 3.7% (p value=0.260). However, it decreased the value of DII by maximum 18% when patients' breast shapes fitted in with the compensator
geometry.
Conclusion: The multistatic field technique is effective for improving dose homogeneity for whole breast radiation therapy and is applicable to all patients, whereas the use of universal compensators is effective only in patients whose
breast
shapes fit inwith the universal compensator geometry, and thus has limited applicability.

Å°¿öµå

À¯¹æº¸Á¸ ¼ö¼ú ÈÄ ¹æ»ç¼±Ä¡·á; ¼±·®ºÐÆ÷; ¼¼±âº¯Á¶ Á¶»ç¼±; º¸»óü; Breast radiotherapy; Dose homogeneity; Intensity modulated beam; Compensator;

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