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°í¼±·®·ü °­³»Á¶»ç¼±¿øÀ» ÀÌ¿ëÇÑ ±ÙÁ¢Á¶»ç¼±·®°èȹÀü»êÈ­ °³¹ß Development of Dose Planning System for Brachytherapy with High Dose Rate Using Ir-192 Source

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ÃÖÅÂÁø/Tae Jin Choi ¿¹Áö¿ø/±èÁøÈñ/±è¿Á¹è/ÀÌÈ£ÁØ/ÇÑÇö¼ö/Ji Won Yei/Jin Hee Kim/Ok Kim /Ho Joon Lee/Hyun Soo Han

Abstract

¸ñÀû: °í¼±·®·üÀÇ Ir-192 ¼±¿øÀ» ÀÌ¿ëÇÑ ±ÙÁ¢Á¶»çÀÇ ¸ðÀÇÃÔ¿µ ¿µ»óÀ» °³ÀÎÄÄÇ»ÅÍ(PC)¿¡ ÀÔ·ÂÇÏ¿© ÇغÎÇÐÀû ¿µ»ó¿¡ ¼±·®ºÐÆ÷¸¦ ±¸ÇöÇÏ°í È÷½ºÅä±×·¥, ¼±·®-¿ëÀûÈ÷½ºÅä±×·¥ ¹× 3Â÷¿ø ¼±·®ºÐÆ÷¸¦ Àü»êÈ­ÇÏ¿´´Ù.

´ë»ó ¹× ¹æ¹ý: ¼±·®Àü»êÈ­¿¡ ÀÌ¿ëµÈ ¼±¿øÀº ¿ø°Ý±ÙÁ¢Á¶»çÀåÄ¡(Buchler 3K, µ¶ÀÏ)ÀÇ Co-60 ´ëü¼±¿øÀ¸·Î Çѱ¹¿øÀڷ¿¬±¸¼Ò¿Í °øµ¿À¸·Î °³¹ßÇÑ Ir-192ÀÌ´Ù. ¼±¿ø ¸ð¾ç¿¡ ÀÇÁ¸ÇÏ´Â ¼±·®ºÐÆ÷ÀÇ ºñµî¹æ¼ºÀº ¼±¿øÀ» ¹Ì¼Ò ºÐÇÒÇÏ¿© ±¸ÇÑ ¼±·®°ú ¼±¿ø Á߽ɿ¡¼­ Ãø¹æ
±âÁØÁ¡ÀÇ °øÁß¼±·®À» ±âÁØÀ¸·Î ±Ô°ÝÈ­ÇÑ °ªÀ» ÀÌ¿ëÇÏ¿´´Ù. ¼±¿ø ÁÖÀ§ÀÇ Á¶Á÷¼±·®Àº ¼±¿ø Á߽ɿ¡¼­ Ãø¹æÀ¸·Î ½ÇÃøµÈ Á¶Á÷°¨¼è¿Í »ê¶õ¿¡ ÀÇÇÑ º¸Á¤°è¼ö¿Í ¿¡³ÊÁö¿¡ µû¸¥ °ø±â ÀúÁö´É¿¡ ´ëÇÑ Á¶Á÷ÀÇ ÀúÁö´É ºñ·Î °øÁß-Á¶Á÷¼±·® º¯È¯°è¼ö¸¦ Àû¿ëÇÏ°í ±âÁØÁ¡¿¡ ´ëÇØ
±Ô°ÝÈ­ÇÑ
¼±·®·üÇ¥¸¦ °Ë»öÇÏ¿© ¾òµµ·Ï ÇÏ¿´´Ù. ¼±·®°èȹ Àü»êÈ­ °úÁ¤¿¡ ¸ðÀÇÃÔ¿µ ¿µ»óÀÔ·Â, ¼±¿øÀԷ°ú ¼±¿øÀÇ Ãà¸é °áÁ¤°ú ÇغÎÇÐÀû ¿µ»óÀ» ÀÌ¿ëÇÑ ¼±·®ºÐÆ÷¿Í Á¡¼±·®, È÷½ºÅä±×·¥ ¹× ¼±·®-¿ëÀû È÷½ºÅä±×·¥À» ±¸ÇöÇÏ¿´´Ù.

°á°ú: ÀúÀÚµéÀÌ °³¹ßÇÑ ±ÙÁ¢Á¶»ç ¼±·®°èȹ½Ã½ºÅÛ¿¡´Â ¼±¿ø¸ðÀÇÃÔ¿µ ¿µ»óÀ» ½ºÄËÇÏ¿© ºñÆ®¸Ê ÆÄÀÏ·Î ÀúÀåÇÏ°í, ÁÂÇ¥¿øÁ¡°ú È®´ëÀ²À» Á¤ÇØ, ¼±¿øÀ§Ä¡¸¦ °áÁ¤ÇÏ°í ¼±·®ºÐÆ÷¿Í ¼±·®ºÐ¼® ÇÁ·Î±×·¥À» Æ÷ÇÔÇÑ ¼±·®Àü»êÈ­¸¦ ±¸ÇöÇÏ¿´´Ù. ½ÇÇè¿¡ ÀÌ¿ëµÈ Ir-192 ¼±¿øÀÇ
Á¶Á÷³»
¼±·®Àº °øÁß¼±·®À²°ú Á¶Á÷¿¡ ÀÇÇÑ °¨¼è ¹× »ê¶õ¿¡ ÀÇÇÑ ½ÇÇè½ÄÀ» ÀÌ¿ëÇÏ¿´´Ù. ¼±¿ø Á߽ɿ¡¼­ Ãà»óÀÇ °Å¸®¿Í Ãà¿¡¼­ ¶³¾îÁø °Å¸®¿¡ µû¸¥ ¼±·®·üÇ¥¿¡¼­ Çà·Ä °Ë»öÇÏ¿© ¾òµµ·Ï ÇÏ¿´´Ù. ±ÙÁ¢Á¶»ç¼±·®°èȹÀº ¼±¿øÁÂÇ¥ ÀԷ°ú ¼±¿øÀÇ Ãà¸é(principal plane)À» °áÁ¤ÇÏ¿©
¼±¿øÀÌ
Æ÷ÇÔµÈ Æò¸é»óÀÇ ¼±·®À» ±¸ÇöÇÏ¿´À¸¸ç, ½Ã¹Ä·¹ÀÌ¼Ç ¿µ»óÀÎ °ü»ó¸é°ú ½Ã»ó¸é¿¡ ¼±·®ºÐÆ÷¸¦ ±¸ÇöÇÏ¿´´Ù. ¼±·®-È÷½ºÅä±×·¥¿¡ ÀÇÇÑ ¼±·®ºÐÆ÷ ºÐ¼®Àº ÀÓÀÇÀÇ ÇغÎÇÐÀû ¿µ»ó¸é À§¿¡ Ä¿¼­°¡ ³õÀÎ À§Ä¡ÀÇ ¼±·® ½ºÄÏÄ¡·Î ¾ò¾ú´Ù. ÀÓ»ó¿¡ ÇÊ¿äÇÑ ¼±·®ºÐ¼®Àº ¼±¿øÀÇ Ãà¿¡¼­
¸éÀÇ
±íÀ̸¦ À̵¿ÇÏ¿© ¼±·®ºÐÆ÷¸¦ ±¸ÇÒ ¼ö ÀÖ°Ô ÇÏ¿´À¸¸ç, ¼±·®-¿ëÀû È÷½ºÅä±×·¥°ú 3Â÷¿ø ¼±·®ºÐÆ÷¸¦ ±¸ÇöÇÏ¿´´Ù.

°á·Ð: °í¼±·®·ü Ir-192¸¦ ÀÌ¿ëÇÏ¿© ±ÙÁ¢Á¶»ç¼±·®°èȹÀ» Àü»êÈ­ÇÏ¿´À¸¸ç, ¼±·®ºÐÆ÷ÀÇ ºÐ¼®¿¡´Â ÇغÎÇÐÀû ¿µ»óÀÇ ¼±·®ºÐÆ÷¿Í ¼±·®-È÷½ºÅä±×·¥, ¼±·®-¿ëÀûÈ÷½ºÅä±×·¥À» ±¸ÇöÇÏ¿´À¸¸ç, ¼±·®ºÐÆ÷ÀÇ ¸éÀ» ÀÓÀÇ ¼±ÅÃÇÒ ¼ö ÀÖ°í 3Â÷¿ø ¼±·®ºÐÆ÷¸¦ Æ÷ÇÔÇÑ
¼±·®°èȹ½Ã½ºÅÛÀ»
ÁغñÇÏ¿´´Ù.

Purpose: A PC based brachytherapy planning system was developed to display dose distributions on simulation images by 2D isodose curve including the dose profiles, dose-volume histogram and 3D dose distributions.

Materials and Methods: Brachytherapy dose planning software was developed especially for the Ir-192 source, which had been developed by KAERI as a substitute for the Co-60 source. The dose computation was achieved by searching for a
pre-computed
dose matrix which was tabulated as a function of radial and axial distance from a source. In the computation process, the effects of the tissue scattering correction factor and anisotropic dose distributions were included. The computed dose
distributions were displayed in 2D film image including the profile dose, 3D isodose curves with wire frame forms and dose- volume histogram.

Results: The brachytherapy dose plan was initiated by obtaining source positions on the principal plane of the source axis. The dose distributions in tissue were computed on a 200¡¿200 (§±) plane on which the source axis was located at the
center
of the plane. The point doses along the longitudinal axis of the source were 4.5¡­9.0% smaller than those on the radial axis of the plane, due to the anisotropy created by the cylindrical shape of the source. When compared to manual calculation,
the
point doses showed 1¡­5% discrepancies from the benchmarking plan. The 2D dose distributions of different planes were matched to the same administered isodose level in order to analyze the shape of the optimized dose level. The accumulated
dose-volume
histogram, displayed as a function of the percentage volume of administered minimum dose level, was used to guide the volume analysis.

Conclusion: This study evaluated the developed computerized dose planning system of brachytherapy. The dose distribution was displayed on the coronal, sagittal and axial planes with the dose histogram. The accumulated DVH and 3D dose
distributions provided by the developed system may be useful tools for dose analysis in comparison with orthogonal dose planning.

Å°¿öµå

±ÙÁ¢Á¶»ç ¼±·®°èȹ; Ir-192 ¼±¿ø; 3D¼±·®ºÐÆ÷; ¼±·®-¿ëÀû È÷½ºÅä±×·¥; Dose planning system; Ir-192 source; 3-D dose plan; Dose-volume histogram;

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