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ÀڱþÏÀÇ °í¼±·®À² ±ÙÁ¢ ¹æ»ç¼±Ä¡·á½Ã Àü»êÈ­ Ä¡·á°èȹ ½Ã½ºÅÛ°ú in vivo dosimetry system À» ÀÌ¿ëÇÏ¿© ÃøÁ¤ÇÑ Á÷Àå ¼±·® ºñ±³ Comparison between the Calculated and Measured Doses in the Rectum during High Dose Rate Brachytherapy for Uterine Cervical Carcinomas

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Á¤ÀºÁö/Eun Ji Chung ÀÌ»óÈÆ/Sang Hoon Lee

Abstract

¸ñÀû: ÀڱþÏÀÇ ¹æ»ç¼±Ä¡·á½Ã È£¹ßÇÏ´Â Á÷Àå ºÎÀÛ¿ëÀº Á÷Àå ¹æ»ç¼±·®°ú °ü°è°¡ ÀÖ´Ù´Â º¸°íµéÀÌ ¸¹´Ù. ICRU 38¿¡ µû¸¥ Á÷Àå ¼±·®À» ÃøÁ¤ÇÔÀ¸·Î °­³» ¹æ»ç¼±Ä¡·á ½Ã¿¡ Á¶»çµÇ´Â Á÷Àå¼±·®ÀÇ Á¤µµ °ü¸®¿¡ ±â¿©ÇÒ ¼ö ÀÖ´Ù°í »ý°¢ÇÏ¿© Àü»ê»ó °è»êµÈ ¼±·®°ú
°­³»Ä¡·á½Ã
´ÙÀÌ¿Àµå °ËÃâ±â·Î Á÷Á¢ ÃøÁ¤µÈ Á÷Àå ¼±·®ÀÇ Â÷À̸¦ ºñ±³ÇØ º¸°íÀÚ ÇÏ¿´´Ù.

´ë»ó: 2001³â 6¿ù-2002³â 2¿ù±îÁö °í¼±·®À² Iridium-192 µ¿À§¿ø¼Ò¸¦ ÀÌ¿ëÇÏ¿© °í¼±·®À² °­³» ¹æ»ç¼±Ä¡·á¸¦ ½ÃÇà ¹ÞÀº ÀڱðæºÎ¾Ï ȯÀÚ 9¸íÀ» ´ë»óÀ¸·Î ÇÏ¿´´Ù. °­³»Ä¡·á´Â ÁÖ 2ȸ¾¿ AÁ¡¿¡ ÃÑ 6~8ȸ°£ ÃÑ 28~32 §í ½ÃÇàµÇ¾ú´Ù. 9¸í¿¡¼­ ÃÑ 44ȸÀÇ °­³»Ä¡·á Áß
¼±·®
ÃøÁ¤ÀÌ °¡´ÉÇÏ¿´°í, ¸ðÀÇÄ¡·á °èȹ½ÃÀÇ Çʸ§ ¹× ºÐÇÒ °í¼±·®À² °­³» ¹æ»ç¼±Ä¡·á ½Ã¿¡ ÃÔ¿µÇÑ Çʸ§À» ±âÁØÀ¸·Î Àü»êÈ­ °èȹ ½Ã½ºÅÛ»ó °è»êÇÑ Á÷Àå ±âÁØÁ¡ ¼±·®°ú °­³»Ä¡·á¸¦ Çϸ鼭 ´ÙÀÌ¿Àµå Á÷Àå °ËÃâ±â¿¡¼­ ÃøÁ¤µÈ ¼±·®À» °¢°¢ ºÐ¼®ÇÏ¿´´Ù.

°á°ú: ¸ðÀÇÄ¡·á½Ã Çʸ§À» ±âÁØÇÑ Á÷ÀåÀÇ Àü»êÈ­ °èȹ»óÀÇ ¼±·®°ú °­³»Ä¡·á ½Ã¸¶´Ù ÃÔ¿µÇÑ Çʸ§À¸·Î ´Ù½Ã Àü»êÈ­ °èȹ»ó °è»êÇÑ Á÷Àå¼±·®°ª »çÀÌ¿¡´Â »ó´çÇÑ Â÷ÀÌ°¡ ÀÖ¾ú´Ù. °­³»Ä¡·á½Ã¿¡ ÃÔ¿µÇÑ »çÁøÀ» ±âÁØÀ¸·Î Àü»êÈ­ ¼³°è¿¡¼­ °è»êµÈ °ª°ú °­³»Ä¡·á Áß¿¡
°ËÃâ±â·Î ÃøÁ¤ÇÑ Á÷Àå ¼±·® »çÀÌ¿¡µµ Â÷ÀÌ°¡ ¸¹¾Ò´Ù. Á÷Àå °ËÃâ±â Ç¥½ÃÁ¡ÀÇ Ä¡·á°èȹ ¼±·®À» 5°³ Á¡¿¡¼­ °è»êÇØ º¸¾ÒÀ» ¶§ ICRU 38 Á÷Àå ±âÁØÁ¡ÀÌ ÃÖ´ë Á÷Àå ¼±·®Á¡°ú ÀÏÄ¡ÇÏ´Â °æ¿ì´Â 22.2% (2/9)¿¡ ºÒ°úÇÏ¿´´Ù.

°á·Ð: ÀڱþϿ¡¼­ °í¼±·®À² °­³» ¹æ»ç¼±Ä¡·á ¼±·®À» °èȹÇÒ ¶§ ¸ðÀÇ Ä¡·á½Ã ÃÔ¿µÇÑ Çʸ§¸¸ °¡Áö°í Á÷Àå ¼±·®À» ÃÖÀûÈ­ÇÏ´Â °ÍÀÌ °¡Àå ÀûÀýÇÑ ¹æ¹ýÀ̶ó°í º¼ ¼ö´Â ¾ø´Ù. º» ¿¬±¸¸¦ ÅëÇØ °í¼±·®À² °­³»Ä¡·á ½ÃÀÇ Á÷Àå ¼±·®ÀÌ Ä¡·á½Ã¸¶´Ù »ó´çÈ÷ º¯È­°¡ ¸¹´Ù´Â
»ç½ÇÀ»
È®ÀÎÇÏ¿´À¸¹Ç·Î °¡´ÉÇϸé Á÷Àå¼±·®À» ½ÇÃøÇϰųª ¾Æ´Ï¸é ÃÖ¼ÒÇÑ Á÷ÀåÇ¥Áö±â¸¦ »ðÀÔÇÏ°í Ãø¹æ Åõ½Ã¸¦ ÇÔÀ¸·Î Á÷Àå À§Ä¡¸¦ ÆľÇÇÏ´Â °ÍÀÌ ÀڱþÏÀÇ °í¼±·®À² °­³» ¹æ»ç¼±Ä¡·á¿¡¼­ Á¤µµ°ü¸® ¸é¿¡¼­ Áß¿äÇÑ °úÁ¤À̶ó »ý°¢ÇÑ´Ù.

Purpose: Many papers support a correlation between rectal complications and rectal doses in uterine cervical cancer patients treated with radical radiotherapy. In vivo dosimetry in the rectum following the ICRU report 38 contributes to the
quality assurance in HDR brachytherapy, especially in minimizing side effects. This study compares the rectal doses calculated in the radiation treatment planning system to that measured with a silicon diode the in vivo dosimetry system.

Methods: Nine patients, with a uterine cervical carcinoma, treated with Iridium-192 high dose rate brachytherapy between June 2001 and Feb. 2002, were retrospectively analysed. Six to eight-fractions of high dose rate (HDR)-intracavitary
radiotherapy (ICR) were delivered two times per week, with a total dose of 28~32 §í to point A. In 44 applications, to the 9 patients, the measured rectal doses were analyzed and compared with the calculated rectal doses using the radiation
treatment
planning system. Using graphic approximation methods, in conjunction with localization radiographs, the expected dose values at the detector points of an intrarectal semiconductor dosimeter, were calculated.

Results: There were significant differences between the calculated rectal doses, based on the simulation radiographs, and the calculated rectal doses, based on the radiographs in each fraction of the HDR ICR. Also, there were significant
differences between the calculated and measured rectal doses based on the in-vivo diode dosimetry system. The rectal reference point on the anteroposterior line drawn through the lower end of the uterine sources, according to ICRU 38 report,
received
the maximum rectal doses in only 2 out of the nine patients (22.2%).

Conclusion: In HDR ICR planning for cervical cancer, optimization of the dose to the rectum by the computer-assisted planning system, using radiographs in simulation, is improper. This study showed that in vivo rectal dosimetry, using a
diode
detector during the HDR ICR, could have a useful role in quality control for HDR brachytherapy in cervical carcinomas. The importance of individual dosimeters for each HDR ICR is clear. In some departments that do not have the in vivo dosimetry
system,
the radiation oncologist has to find, from lateral fluoroscopic findings, the location of the rectal marker before each fractionated HDR brachytherapy, which is a necessary and important step of HDR brachytherapy for cervical cancer.

Å°¿öµå

ÀڱñðæºÎ¾Ï; ¹æ»ç¼±Ä¡·á; °­³» ¹æ»ç¼±Ä¡·á; in vivo dosimetry; Cervical cancer; Radiotherapy; Brachytherapy; In vivo dosimetry;

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