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Àü¸³¼±¾Ï ±ÙÁ¢Ä¡·á ½Ã ¹æ»ç¼º¼±¿ø À§Ä¡È®ÀÎÀ» À§ÇÑ ¿µ»ó À籸¼º¿¡ °üÇÑ ¿¬±¸ A Study on Image Reconstruction for Seed Localization for Permanent Prostate Brachytherapy

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È«ÁÖ¿µ, ¼­Å¼®, ¶óÁ¤Àº,
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È«ÁÖ¿µ ( Hong Ju-Young ) 
°¡Å縯´ëÇб³ ÀÇ°ú´ëÇÐ ÀÇ°øÇб³½Ç

¼­Å¼® ( Suh Tae-Suk ) 
°¡Å縯´ëÇб³ ÀÇ°ú´ëÇÐ ÀÇ°øÇб³½Ç
¶óÁ¤Àº ( Ra Jung-En ) 
°¡Å縯´ëÇб³ ÀÇ°ú´ëÇÐ ÀÇ°øÇб³½Ç

Abstract

¸ñ Àû: ¿Ïº®ÇÏ°Ô Áߺ¹µÈ ¹æ»ç¼º¼±¿øÀÇ À§Ä¡¸¦ ÆǺ°Çϱâ À§ÇØ Á÷Á¢ ¼³°è ¹× Á¦ÀÛÇÑ ÆÒÅèÀ» ÀÌ¿ëÇÏ¿© ¿µ»óÀ» ¿µ»óó¸® °úÁ¤À» °ÅÄ£ ÈÄ 3¹æÇâ Çʸ§ ±â¹ý°ú °³¹ßÇÑ ÇÁ·Î±×·¥À» ÀÌ¿ëÇÏ¿© ¿Ïº®ÇÏ°Ô Áߺ¹µÈ ¹æ»ç¼±¿øÀ» ºÐ¸®Çس»°íÀÚ ÇÑ´Ù.

´ë»ó ¹× ¹æ¹ý: ÆÒÅè ³»¿¡ »ðÀÔµÈ ¹æ»ç¼º¼±¿øÀÇ À§Ä¡È®ÀÎÀ» À§ÇÏ¿© ÀüÈÄ ¹æÇâ ¹× -30o¿¡¼­ 30o±îÁö 15o°£°ÝÀ¸·Î ¿µ»óÀ» ȹµæÇÏ¿´´Ù. ȹµæÇÑ ¿µ»óÀº ºÒÇÊ¿äÇÑ ¹è°æÁ¦°Å¿Í È­Áú°³¼±À» À§ÇÑ ¿µ»óó¸® °úÁ¤À» °ÅÃÄ ÇÁ·Î±×·¥¿¡ »ç¿ëÇÏ¿´´Ù. º» ¿¬±¸¿¡¼­´Â 1°³ÀÇ ¹æ»ç¼º¼±¿øÀÌ Áߺ¹µÈ »óȲ, 2°³ ÀÌ»óÀÇ ¹æ»ç¼º¼±¿øÀÌ Áߺ¹µÈ »óȲ ±×¸®°í ¹æ»ç¼º¼±¿øÀÌ Áߺ¹µÇ¾î 3ÀåÀÇ ¿µ»ó ¸ðµÎ¿¡¼­ »ðÀÔµÈ ¹æ»ç¼º¼±¿øÀÇ Àüü °³¼ö¸¦ È®ÀÎÇÒ ¼ö ¾ø´Â »óȲÀ» ¼³Á¤ÇÏ¿© ½ÇÇèÇÏ¿´´Ù. °³¹ßµÈ ÇÁ·Î±×·¥Àº Åõ»ç¿µ»ó¿¡¼­ ÀÏÁ¤ÇÑ ¿µ¿ªÀ» ¼³Á¤ÇÏ¿© À§Ä¡¸¦ È®ÀÎÇÏ°íÀÚ ÇÏ´Â ¹æ»ç¼º¼±¿ø°ú ±âÁØÀÌ µÇ´Â ¹æ»ç¼º¼±¿øÀÇ Á߽ɰ£ÀÇ °Å¸®¸¦ °è»êÇÏ¿© °¢°¢ÀÇ Çʸ§ ³»¿¡¼­ µ¿ÀÏÇÑ °úÁ¤À» ¹Ýº¹ÇÏ¿© ¿Ïº®ÇÏ°Ô Áߺ¹µÈ ¹æ»ç¼º¼±¿øÀ» ºÐ¸®ÇÏ°Ô µÈ´Ù. ¶ÇÇÑ ÀüÅëÀûÀÎ 2¹æÇâ Çʸ§±â¹ýÀ» ÀÌ¿ëÇÏ¿© Áߺ¹µÈ ¹æ»ç¼º¼±¿øÀÇ À§Ä¡¸¦ È®ÀÎÇÏ¿© ºñ±³ÇÏ¿´´Ù.

°á °ú: °¢ ¹æ¹ýÀÇ À§Ä¡ È®ÀÎÀ²Àº ¡¾15o¿¡¼­´Â 92.2%, ¡¾30o¿¡¼­´Â 94.1% ±×¸®°í 2¹æÇâ Çʸ§±â¹ý¿¡¼­´Â 70.6%·Î ³ªÅ¸³µ´Ù. 1°³ÀÇ ¹æ»ç¼º¼±¿øÀÌ Áߺ¹µÈ »óȲ°ú 2°³ ÀÌ»óÀÇ ¹æ»ç¼º¼±¿øÀÌ Áߺ¹µÈ »óȲ¿¡¼­´Â ¿Ïº®ÇÏ°Ô ºÐ¸®°¡ °¡´ÉÇÏ¿´Áö¸¸ 3ÀåÀÇ ¿µ»ó¿¡¼­ È®ÀÎÇÏ°íÀÚ ÇÏ´Â ¹æ»ç¼º¼±¿øÀÌ ¶Ç ´Ù¸¥ ¹æ»ç¼º¼±¿ø°ú Áߺ¹µÇ¾î ³ªÅ¸³ªÁö ¾Ê´Â »óȲ¿¡¼­´Â ÁÖ¸ñÇÒ ¸¸ÇÑ °á°ú¸¦ °¡Á®¿ÀÁö ¸øÇß´Ù.

°á ·Ð: Àü¸³¼±¾Ï ±ÙÁ¢Ä¡·á½Ã º» ¿¬±¸¿¡¼­ °³¹ßÇÑ ÇÁ·Î±×·¥À» ÀÌ¿ëÇÑ´Ù¸é ¿Ïº®ÇÏ°Ô Áߺ¹µÈ ¹æ»ç¼º¼±¿øÀ¸·Î ÀÇÇØ À籸¼ºÇÏ´Â °úÁ¤¿¡¼­ »ý±â´Â ¿ÀÂ÷¸¦ ÁÙÀÏ ¼ö ÀÖ¾î Ä¡·á È¿°ú Çâ»ó¿¡ ±â¿©ÇÒ °ÍÀ¸·Î ¿¹»óµÈ´Ù.

Purpose: This study was to design and fabricate a phantom for prostate cancer brachytherapy to validate a developed program applying a 3-film technique, and to compare it with the conventional 2-film technique for determining the location of an implanted seed.

Materials and Methods: The images were obtained from overlapped seeds by randomly placing a maximum of 63 seeds in the anterior-posterior (AP) position and at -30o to 30o at 15o intervals. Images obtained by use of the phantom were applied to the image processing procedure, and were then processed into the development program for seed localization. In this study, cases were set where one seed overlapped, where two seeds overlapped and where none of the three views resolved all seeds. The distance between the centers of each seed to the reference seed was calculated in a prescribed region. This distance determined the location of each seed in a given band. The location of the overlapped seeds was compared with that of the 2-film technique.

Results: With this program, the detection rate was 92.2% (at ¡¾15o), 94.1% (at ¡¾30o) and 70.6% (compared to the use of the 2-film technique). The overlaps were caused by one or more than two seeds that overlapped; the developed program can identify the location of each seed perfectly. However, for the third case the program was not able to resolve the overlap of the seeds.

Conclusion: This program can be used to improve treatment outcome for the brachytherapy of prostate cancer by reducing the number of errors in the process of reconstructing the locations of perfectly overlapped seeds.

Å°¿öµå

Àü¸³¼±¾Ï; ±ÙÁ¢Ä¡·á; ¹æ»ç¼±¿ø Áߺ¹; À§Ä¡È®ÀÎ
Prostate cancer; Brachytherapy; Overlap seeds; Localization

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