안검하수 및 연하곤란으로 발현된 Lambert-Eaton Myasthenic Syndrome 1예
A case of Lambert-Eaton Myasthenic Syndrome with Ptosis and Dysphagia
권유석, 유현정, 노숙영, 백소야,
소속 상세정보
권유석 ( Kwon Yoo-Seok )
분당제생병원 신경과
유현정 ( Yu Hyun-Jeung )
분당제생병원 신경과
노숙영 ( Roh Sook-Young )
분당제생병원 신경과
백소야 ( Paik So-Ya )
분당제생병원 진단병리과
KMID : 0860920060080020146
Abstract
Lambert-Eaton myasthenic syndrome (LEMS) is an uncommon presynaptic disorder caused by voltagegated calcium channel antibodies. Typical symptoms of LEMS include proximal leg weakness, dry mouth, and areflexia. We present an case of LEMS showing ptosis and dysphagia with normal motor power, and diagnosed as small-cell lung cancer. A 62-year-old woman was admitted because of persistent gait ataxia for two months. Diplopia, ptosis, and dysphagia were developed a week after the admission. She said these symptoms were fluctuating; becoming severe in the morning but relieved in the evening. She had normal motor power, and deep tendon reflex was hypoactive. There was no abnormal finding in the brain MRI. The amplitude of compound muscle action potentials (CMAPs) went down over 20 percent during low frequency stimulation of abductor digiti quinti muscle, but significantly went up during 50 Hz stimulation. A mediastinal mass was found in chest CT and was finally diagnosed as metastatic small-cell lung cancer. We experienced a case of LEMS combined with cerebellar degeneration initially showing gait ataxia, followed by ptosis and dysphagia.
키워드
Lambert-Eaton myasthenic syndrome;Ptosis;Dysphagia
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